产品名称
碘乙酸, ≥98.0% (T)
Quality Level
InChI key
JDNTWHVOXJZDSN-UHFFFAOYSA-N
InChI
1S/C2H3IO2/c3-1-2(4)5/h1H2,(H,4,5)
SMILES string
OC(=O)CI
biological source
synthetic
assay
≥98.0% (T)
form
powder or flakes
color
white to yellow
mp
77-79 °C (lit.)
solubility
H2O: soluble, clear to hazy
storage temp.
−20°C
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Application
碘乙酸用作:烷基化剂,适用抗体AR37、 血清蛋白、 和从成熟果实不同阶段提取的草莓蛋白质组样品。
蛋白质中半胱氨酸残基的改性剂。
Biochem/physiol Actions
碘乙酸(IAA)封闭半胱氨酸的巯基。通过与半胱氨酸活性位点的巯基相互作用,IAA抑制3-磷酸甘油醛脱氢酶(G3PDH)。IAA 抑制实体艾氏(Ehrlich)癌的进展。IAA 是饮用水进行碘化消毒的一种副产物。对哺乳动物细胞存在细胞毒性。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1A
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
危险化学品
此项目有
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Wei X, et al.
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Carboxymethylation of cysteine using iodoacetamide/iodoacetic acid
The Protein Protocols Handbook, 455-456 (2002)
Development of candidate biomarkers for pancreatic ductal adenocarcinoma using multiple reaction monitoring
Yu J, et al.
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