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文件

L0750000

洛哌丁胺盐酸盐

Name: 洛哌丁胺 盐酸盐
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

4-（ p -氯苯基）-4-羟基- N,N -二甲基-α,α-二苯基-1-哌啶丁酰胺盐酸盐

经验公式（希尔记法）:

C₂₉H₃₃ClN₂O₂ · HCl

CAS号:

34552-83-5

分子量:

513.50

MDL编号:

MFCD00058581

PubChem化学物质编号:

329817374

NACRES:

NA.24

等级

pharmaceutical primary standard

Agency

EP Reference Standard

API类

loperamide

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

格式

neat

SMILES字符串

Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4

InChI

1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H

InChI key

PGYPOBZJRVSMDS-UHFFFAOYSA-N

基因信息

human ... OPRM1(4988)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Loperamide hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

1370000

洛哌丁胺盐酸盐, United States Pharmacopeia (USP) Reference Standard

Y0000341

洛哌丁胺一水合物, European Pharmacopoeia (EP) Reference Standard

1370065

PHR2916

象形图

GHS06

警示用语：

Danger

危险声明

H301

预防措施声明

P301 + P310 + P330

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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Effect of colic vein ligature in rats with loperamide-induced constipation.

Flavia Neri et al.

Journal of biomedicine & biotechnology, 2012, 896162-896162 (2012-06-01)

Medical treatment in chronic constipation is not always successful. Surgery is indicated in unresponsive selected severe cases. This study presents the distal venous colic ligation in rat as a novel surgical approach. 16 rats (study group) were evaluated in 3

Garcinia buchananii bark extract is an effective anti-diarrheal remedy for lactose-induced diarrhea.

Paul A Boakye et al.

Journal of ethnopharmacology, 142(2), 539-547 (2012-05-31)

The extract from the stem bark of Garcinia buchananii trees is used as an anti-diarrhea remedy in sub-Saharan Africa. We tested the hypothesis that G. buchananii bark extract and its anti-motility fractions are effective treatments against lactose-induced diarrhea. A high-lactose

Behavior of printable formulations of loperamide and caffeine on different substrates--effect of print density in inkjet printing.

Natalja Genina et al.

International journal of pharmaceutics, 453(2), 488-497 (2013-06-19)

The primary goal of the current work was to study the applicability of precision inkjet printing in fabrication of personalized doses of active pharmaceutical ingredients (APIs). Loperamide hydrochloride (LOP) and caffeine (CAF) were used as model compounds. Different doses of

Irritable bowel syndrome--diarrhoea.

Arnold Wald

Best practice & research. Clinical gastroenterology, 26(5), 573-580 (2013-02-07)

IBS is a functional gastrointestinal disorder which has been subtyped according to bowel habits. This review presents recommendations for IBS-D which makes up about 1/3 of all patients and which is defined as IBS with loose or watery stools with

Local loperamide injection reduces mechanosensitivity of rat cutaneous, nociceptive C-fibers.

Matthias Ringkamp et al.

PloS one, 7(7), e42105-e42105 (2012-08-01)

Loperamide reverses signs of mechanical hypersensitivity in an animal model of neuropathic pain suggesting that peripheral opioid receptors may be suitable targets for the treatment of neuropathic pain. Since little is known about loperamide effects on the responsiveness of primary

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洛哌丁胺 盐酸盐