M4627
1-甲基烟酰胺氯化物
analytical standard
别名:
N-甲基烟酸氯代酰胺
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关于此项目
线性分子式:
C7H9N2OCl
化学文摘社编号:
分子量:
172.61
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H
SMILES string
[Cl-].C[n+]1cccc(c1)C(N)=O
InChI key
BWVDQVQUNNBTLK-UHFFFAOYSA-N
grade
analytical standard
assay
≥97.5%
form
powder
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
color
white
application(s)
forensics and toxicology
veterinary
vitamins, nutraceuticals, and natural products
format
neat
Quality Level
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General description
1-甲基烟酰胺（MNA）是主要由烟酰胺N-甲基转移酶（NNMT）产生的烟酰胺的主要代谢产物，具有抗血栓形成和抗炎作用。
Application
1-甲基烟酰胺氯化物可用作使用离子对反相高效液相色谱法（RP-HPLC）定量尿液样品中1-甲基烟酰胺的标准品。
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Biochem/physiol Actions
烟酸代谢的尿排泄产物
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Quantitation of the niacin metabolites 1-methylnicotinamide and l-methyl-2-pyridone-5-carboxamide in random spot urine samples, by ion-pairing reverse-phase HPLC with UV detection, and the implications for the use of spot urine samples in the assessment of niacin status
Creeke IP, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 817, 247-253 (2005)
Jacek Miedzobrodzki et al.
Acta poloniae pharmaceutica, 67(5), 487-494 (2010-09-30)
The study was designed to demonstrate the relationship between the activity of human normal monocytes and blood platelets, to determine the metabolic activity of normal monocytes and monocytes cooperating with blood platelets in respect of their generation of reactive oxygen
Yoshitaka Tayama et al.
Drug metabolism and pharmacokinetics, 26(1), 94-101 (2010-11-19)
Aldehyde oxidase (AO) plays an important role in metabolizing antitumor and antiviral drugs, including methotrexate, cyclophosphamide and acyclovir. Green tea and its catechins have been shown to modulate the activities of various xenobiotic-metabolizing cytochrome P450 species, both in vivo and
Magdalena Sternak et al.
Pharmacological reports : PR, 62(3), 483-493 (2010-07-16)
Nicotinamide N-methyltransferase (NNMT), which converts nicotinamide (NA) to 1-methylnicotinamide (MNA), is up-regulated in the cirrhotic liver. Because MNA displays PGI(2)-dependent anti-inflammatory effects, the up-regulation of NNMT may play a regulatory role in liver inflammation. In the present work, we analyzed
Stefan Chłopicki et al.
Pharmacological reports : PR, 64(2), 369-376 (2012-06-05)
Methylnicotinamide (MNA) displays vasoprotective activity, however, the regulation of the activity of nicotinamide-N-methyltransferase (NNMT), is largely unknown. We analyze a possible involvement of IL-6 in the activation of NNMT-MNA pathway during an endurance exercise. FVB, C57Bl/6J IL6(+/+) and C57Bl/6J IL-6(-/-)
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