等级
analytical standard
质量水平
方案
≥97.5%
表单
powder
技术
HPLC: suitable
gas chromatography (GC): suitable
颜色
white
应用
forensics and toxicology
veterinary
vitamins, nutraceuticals, and natural products
包装形式
neat
SMILES字符串
[Cl-].C[n+]1cccc(c1)C(N)=O
InChI
1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H
InChI key
BWVDQVQUNNBTLK-UHFFFAOYSA-N
一般描述
1-甲基烟酰胺（MNA）是主要由烟酰胺N-甲基转移酶（NNMT）产生的烟酰胺的主要代谢产物，具有抗血栓形成和抗炎作用。
应用
1-甲基烟酰胺氯化物可用作使用离子对反相高效液相色谱法（RP-HPLC）定量尿液样品中1-甲基烟酰胺的标准品。
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生化/生理作用
烟酸代谢的尿排泄产物
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Zuzana Országhová et al.
Redox report : communications in free radical research, 17(1), 1-7 (2012-02-22)
This study was focused on the monitoring how the anti-inflammatory substance, N(1)-methylnicotinamide (MNA), could influence oxidation and glycooxidation stress markers in rats under conditions of streptozotocin (STZ)-induced diabetes mellitus. Diabetes mellitus was induced in 60 male Wistar rats by intraperitoneal
Richard B Parsons et al.
The Biochemical journal, 436(1), 145-155 (2011-03-01)
NNMT (nicotinamide N-methyltransferase, E.C. 2.1.1.1) catalyses the N-methylation of nicotinamide to 1-methylnicotinamide. NNMT expression is significantly elevated in a number of cancers, and we have previously demonstrated that NNMT expression is significantly increased in the brains of patients who have
Da Li et al.
Pharmaceutical biology, 51(1), 8-12 (2012-09-14)
Recent ecological evidence has showed a lag-correlation between the prevalence of diabetes and consumption of niacin (nicotinamide and nicotinic acid) in the US. Nicotinamide has been demonstrated to induce insulin resistance due to excess reactive oxygen species and methyl depletion
Jacek Miedzobrodzki et al.
Acta poloniae pharmaceutica, 67(5), 487-494 (2010-09-30)
The study was designed to demonstrate the relationship between the activity of human normal monocytes and blood platelets, to determine the metabolic activity of normal monocytes and monocytes cooperating with blood platelets in respect of their generation of reactive oxygen
Stefan Chłopicki et al.
Pharmacological reports : PR, 64(2), 369-376 (2012-06-05)
Methylnicotinamide (MNA) displays vasoprotective activity, however, the regulation of the activity of nicotinamide-N-methyltransferase (NNMT), is largely unknown. We analyze a possible involvement of IL-6 in the activation of NNMT-MNA pathway during an endurance exercise. FVB, C57Bl/6J IL6(+/+) and C57Bl/6J IL-6(-/-)
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