M8277
甲氧胺福林 盐酸盐
analytical standard, for drug analysis
别名:
2-氨基-N-[2-(2,5-二甲氧基苯基)-2-羟乙基]乙酰胺
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关于此项目
经验公式（希尔记法）:
C12H18N2O4 · HCl
化学文摘社编号:
分子量:
290.74
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
质量水平
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
forensics and toxicology
pharmaceutical (small molecule)
veterinary
包装形式
neat
SMILES字符串
Cl.COc1ccc(OC)c(c1)C(O)CNC(=O)CN
InChI
1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H
InChI key
MGCQZNBCJBRZDT-UHFFFAOYSA-N
基因信息
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
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一般描述
Midodrine is a prodrug and a long acting α-adrenergic stimulating agent, and forms an active metabolite, desglymidodrine, which causes an elevation of the systemic blood pressure with the reduction in heart rate.
应用
Midodrine hydrochloride may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations using different chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
生化/生理作用
α-肾上腺素激动剂；血管收缩剂
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
此项目有
Horacio Kaufmann et al.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 22(2), 79-90 (2011-11-03)
There is no widely accepted validated scale to assess the comprehensive symptom burden and severity of neurogenic orthostatic hypotension (NOH). The Orthostatic Hypotension Questionnaire (OHQ) was developed, with two components: the six-item symptoms assessment scale and a four-item daily activity
Ying Liao et al.
The American journal of cardiology, 112(6), 816-820 (2013-06-06)
This study was designed to explore the value of flow-mediated vasodilation (FMD) as a predictor of therapeutic response to midodrine hydrochloride (MD) in children with postural orthostatic tachycardia syndrome (POTS). One hundred and eight children diagnosed with POTS and 20
Jinyan Yang et al.
The Journal of pediatrics, 163(4), 1169-1173 (2013-06-04)
To evaluate the use of erythrocytic hydrogen sulfide (H2S) in predicting the therapeutic efficacy of midodrine hydrochloride for children with postural orthostatic tachycardia syndrome (POTS). Fifty-five children were included in this study, involving 28 children with POTS (POTS group) and
Satish R Raj et al.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 22(6), 275-280 (2012-05-23)
Vasovagal syncope is a common problem associated with a poor quality of life, which improves when the frequency of syncope is reduced. Effective pharmacological therapies for vasovagal syncope have been elusive. Midodrine is a pro-drug whose primary metabolite is an
Aaron A Phillips et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(5), 794-801 (2014-01-30)
Individuals with high-level spinal cord injury (SCI) experience low blood pressure (BP) and cognitive impairments. Such dysfunction may be mediated in part by impaired neurovascular coupling (NVC) (i.e., cerebral blood flow responses to neurologic demand). Ten individuals with SCI >T6
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