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Merck
CN

M8277

甲氧胺福林 盐酸盐

analytical standard, for drug analysis

别名:

2-氨基-N-[2-(2,5-二甲氧基苯基)-2-羟乙基]乙酰胺

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关于此项目

经验公式(希尔记法):
C12H18N2O4 · HCl
化学文摘社编号:
分子量:
290.74
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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InChI key

MGCQZNBCJBRZDT-UHFFFAOYSA-N

SMILES string

Cl.COc1ccc(OC)c(c1)C(O)CNC(=O)CN

InChI

1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

Gene Information

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General description

Midodrine is a prodrug and a long acting α-adrenergic stimulating agent, and forms an active metabolite, desglymidodrine, which causes an elevation of the systemic blood pressure with the reduction in heart rate.

Application

Midodrine hydrochloride may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations using different chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

α-肾上腺素激动剂;血管收缩剂

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Stability indicating RP-HPLC assay method for estimation of midodrine hydrochloride in bulk and tablets
Jain.KH, et al.
International Journal of Pharmacy and Pharmaceutical Sciences, 9(9), 283-287 (2016)
Ying Liao et al.
The American journal of cardiology, 112(6), 816-820 (2013-06-06)
This study was designed to explore the value of flow-mediated vasodilation (FMD) as a predictor of therapeutic response to midodrine hydrochloride (MD) in children with postural orthostatic tachycardia syndrome (POTS). One hundred and eight children diagnosed with POTS and 20
D B Barber et al.
Spinal cord, 38(2), 109-111 (2000-04-13)
A report of two cases of orthostatic hypotension in acute tetraplegia that were resistant to classic treatment interventions. To discuss the use of midodrine hydrochloride for the treatment of orthostatic hypotension in early tetraplegia. Department of Rehabilitation Medicine, The University
Horacio Kaufmann et al.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 22(2), 79-90 (2011-11-03)
There is no widely accepted validated scale to assess the comprehensive symptom burden and severity of neurogenic orthostatic hypotension (NOH). The Orthostatic Hypotension Questionnaire (OHQ) was developed, with two components: the six-item symptoms assessment scale and a four-item daily activity
Douglas Z Liou et al.
Chest, 144(3), 1055-1057 (2013-09-07)
Thoracic duct injury is a rare but serious complication following surgery of the neck or chest that leads to uncontrolled chyle leak. Conventional management includes drainage, nutritional modification, or aggressive surgical interventions such as thoracic duct ligation, flap coverage, fibrin

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