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Merck
CN

M8277

甲氧胺福林 盐酸盐

analytical standard, for drug analysis

别名:

2-氨基-N-[2-(2,5-二甲氧基苯基)-2-羟乙基]乙酰胺

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关于此项目

经验公式(希尔记法):
C12H18N2O4 · HCl
化学文摘社编号:
分子量:
290.74
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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InChI key

MGCQZNBCJBRZDT-UHFFFAOYSA-N

SMILES string

Cl.COc1ccc(OC)c(c1)C(O)CNC(=O)CN

InChI

1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

Gene Information

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General description

Midodrine is a prodrug and a long acting α-adrenergic stimulating agent, and forms an active metabolite, desglymidodrine, which causes an elevation of the systemic blood pressure with the reduction in heart rate.

Application

Midodrine hydrochloride may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations using different chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

α-肾上腺素激动剂;血管收缩剂

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Khurram Bari et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 10(10), 1169-1175 (2012-07-18)
Large-volume paracentesis (LVP) is the treatment of choice for patients with cirrhosis and refractory ascites. However, LVP can lead to postparacentesis circulatory dysfunction (PCD), which is associated with faster ascites recurrence and renal failure. PCD results from vasodilatation, which reduces
Amanda B Hassinger et al.
Pediatric nephrology (Berlin, Germany), 28(2), 345-348 (2012-09-21)
Denys-Drash (DDS) syndrome is a rare genetic syndrome resulting from a mutation in the Wilms' tumor suppressor gene 1 (WT1), which presents with early onset nephrotic syndrome progressing rapidly to end-stage kidney disease (ESKD), pseudohermaphroditism, and high rates of Wilms'
Jacques Mansourati
Presse medicale (Paris, France : 1983), 41(11), 1111-1115 (2012-07-24)
Several cardiovascular drugs may induce or worsen orthostatic hypotension especially in patients treated for hypertension, coronary artery disease and heart failure. Orthostatic hypotension is more frequent in polymedicated elderly patients with co-morbidities (prevalence 23%). In hypertensive elderly patients, the combination
Douglas Z Liou et al.
Chest, 144(3), 1055-1057 (2013-09-07)
Thoracic duct injury is a rare but serious complication following surgery of the neck or chest that leads to uncontrolled chyle leak. Conventional management includes drainage, nutritional modification, or aggressive surgical interventions such as thoracic duct ligation, flap coverage, fibrin
Determination of midodrine in human plasma by high-performance liquid chromatography with fluorescence detection
Yoshida H, et al.
Analytical Sciences, 19(2), 317-319 (2003)

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