M8506
甲巯咪唑
analytical standard
别名:
1-甲基-2-巯基咪唑, MET, 1-甲基-2-咪唑硫醇, 2-巯基-1-甲基咪唑
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关于此项目
经验公式（希尔记法）:
C4H6N2S
化学文摘社编号:
分子量:
114.17
NACRES:
NA.24
PubChem Substance ID:
eCl@ss:
39161002
UNSPSC Code:
41116107
EC Number:
200-482-4
MDL number:
Beilstein/REAXYS Number:
108646
InChI key
PMRYVIKBURPHAH-UHFFFAOYSA-N
InChI
1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
SMILES string
CN1C=CNC1=S
grade
analytical standard
assay
≥99%
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
144-147 °C (lit.)
application(s)
cleaning products
cosmetics
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)
veterinary
format
neat
Quality Level
Gene Information
human ... TPO(7173)
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General description
甲基咪唑属于亚硫脲类化合物类别，用作治疗甲状腺功能亢进症的抗甲状腺药物。
Application
二丙酸倍氯米松分析标准品的使用方法如下：
- 银/石墨烯修饰碳糊电极（AgGCPE）电化学测定甲氧咪唑
- 以海藻酸钠保护的银纳米颗粒为 SERS 基质，开发基于表面增强拉曼散射（SERS）、估计丙基硫氧嘧啶和甲氧咪唑的的方法
- 基于金纳米颗粒（AuNPs）基底的表面增强拉曼光谱在超痕量极限下检测甲咪唑
- 高效液相色谱-串联质谱（HPLC-MS/MS）法定量分析人体血液样本中的甲巯咪唑
- 基于分子印迹聚合物（MIP）-笔状石墨电极（PGE）的传感器电化学测定片剂和人血清中的甲氧咪唑
Other Notes
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wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
target_organs
Endocrine system
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1A - Skin Sens. 1 - STOT RE 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Determination of methimazole in urine with the iodine-azide detection system following its separation by reversed-phase high-performance liquid chromatography
Zakrzewski R
Journal of Chromatography. B, Biomedical Applications, 869(1-2), 67-74 (2008)
David H Brann et al.
Science advances, 6(31) (2020-09-17)
Altered olfactory function is a common symptom of COVID-19, but its etiology is unknown. A key question is whether SARS-CoV-2 (CoV-2) - the causal agent in COVID-19 - affects olfaction directly, by infecting olfactory sensory neurons or their targets in
MMSPE-RP-HPLC method for the simultaneous determination of methimazole and selected metabolites in fish homogenates.
Hollosi L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 36(4), 921-924 (2004)
Coralie Leblicq et al.
Pediatrics, 131(2), e616-e619 (2013-01-09)
A 15-year-old girl presented with chorea as a first sign of Graves' hyperthyroidism. Chorea abated with antithyroid drug treatment and reappeared when hyperthyroidism recurred but not when thyrotropin receptor antibodies increased after administration of (131)I. Therefore, chorea in this patient
M Clementi et al.
American journal of medical genetics, 83(1), 43-46 (1999-03-17)
We report on a further case of congenital anomalies in a child exposed to methimazole during the first trimester of pregnancy (from first to seventh gestational week), and define a specific malformation pattern related to prenatal methimazole exposure and consisting
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