M9929

甲氨蝶呤

Name: 甲氨蝶呤
Brand: SIAL

meets USP testing specifications

别名:

甲氨蝶呤水合物, ^{对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸水合物, L-氨甲喋呤水合物, MTX 水合物, 氟安定水合物, 氨甲叶酸水合物, 氨甲喋呤水合物}

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关于此项目

经验公式（希尔记法）:

C₂₀H₂₂N₈O₅ · xH₂O

化学文摘社编号:

133073-73-1

分子量:

454.44 (anhydrous basis)

NACRES:

NA.21

PubChem Substance ID:

24897373

UNSPSC Code:

12352005

MDL number:

MFCD00150847

主要文件

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biological source

synthetic

Quality Level

400

agency

USP/NF, meets USP testing specifications

assay

98.0-102.0%

form

powder

storage condition

(Tightly closed. Dry. Keep in a well-ventilated place. )

technique(s)

activity assay: suitable

impurities

≤0.1% Residue on ignition (Ash), ≤12.0% water (Karl Fischer)

color

yellow to orange-yellow

mp

185-204 °C (365 - 399 °F)

solubility

water: insoluble

antibiotic activity spectrum

parasites

application(s)

metabolomics
microbiology

mode of action

DNA synthesis

storage temp.

−20°C

SMILES string

[H]O[H].CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);1H2/t13-;/m0./s1

InChI key

FPJYMUQSRFJSEW-ZOWNYOTGSA-N

Gene Information

human ... DHFR(1719), DHFRP1(573971), FPGS(2356), SLC19A1(6573), TYMS(7298)
mouse ... Dhfr(13361)
rat ... Dhfr(24312)

Application

二氢叶酸还原酶的有效抑制剂和抗肿瘤的研究试剂。用于抑制二氢叶酸还原酶在DHFR蛋白表达系统中的表达。

二氢叶酸还原酶的有效抑制剂和抗肿瘤的研究试剂。用于抑制二氢叶酸还原酶在DHFR蛋白表达系统中的表达。也显示免疫抑制作用，如类风湿关节炎。

二氢叶酸还原酶的有效抑制剂和抗肿瘤的研究试剂。用于抑制二氢叶酸还原酶在DHFR蛋白表达系统中的表达。还可有效治疗耐甲氧嘧啶的间日疟原虫。

Biochem/physiol Actions

甲氨蝶呤是一种二氢叶酸还原酶(DHFR)的变构抑制剂，DHFR是一种催化二氢叶酸转化为四氢叶酸的酶。由于嘌呤和嘧啶的合成需要四氢叶酸，甲氨蝶呤处理会抑制DNA和RNA的合成。

Other Notes

如需了解生化试剂系列的更多信息，请填写此表。

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H315,H319,H360FD

pcodes

P202 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000523959

0000513219

0000509795

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Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells.

Hany Elsawy et al.

Bioscience reports, 40(6) (2020-05-28)

Methotrexate (MTX) is an efficient chemotherapeutic and immunosuppressant drug, but the hepatotoxicity of MTX limits its clinical use. Naringin (Nar) is a flavonoid derived from Citrus paradise, and has been shown to possess several pharmacological activities, including free-radical scavenging and

Herbo-mineral formulation 'Ashwashila' attenuates rheumatoid arthritis symptoms in collagen-antibody-induced arthritis (CAIA) mice model.

Acharya Balkrishna et al.

Scientific reports, 9(1), 8025-8025 (2019-05-31)

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that affects joints of hands and feet and introduces injury in secondary organs such as cardiac tissue. In the present study, we induced RA in male Balb/c mice (CAIA) using collagen-antibody

A peptide derived from the core β-sheet region of TIRAP decoys TLR4 and reduces inflammatory and autoimmune symptoms in murine models.

Asma Achek et al.

EBioMedicine, 52, 102645-102645 (2020-02-06)

TLRs are some of the actively pursued drug-targets in immune disorders. Owing to a recent surge in the cognizance of TLR structural biology and signalling pathways, numerous therapeutic modulators, ranging from low-molecular-weight organic compounds to polypeptides and nucleic acid agents

Alleviation of Collagen-Induced Arthritis by Crotonoside through Modulation of Dendritic Cell Differentiation and Activation.

Shih-Chao Lin et al.

Plants (Basel, Switzerland), 9(11) (2020-11-14)

Crotonoside, a guanosine analog originally isolated from Croton tiglium, is reported to be a potent tyrosine kinase inhibitor with immunosuppressive effects on immune cells. Due to its potential immunotherapeutic effects, we aimed to evaluate the anti-arthritic activity of crotonoside and

Deep sequencing reveals different compositions of mRNA transcribed from the F8 gene in a panel of FVIII-producing CHO cell lines.

Christian S Kaas et al.

Biotechnology journal, 10(7), 1081-1089 (2015-05-13)

Coagulation factor VIII (FVIII) is one of the most complex biopharmaceuticals due to the large size, poor protein stability and extensive post-translational modifications. As a consequence, efficient production of FVIII in mammalian cells poses a major challenge, with typical yields

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全球贸易项目编号

货号	GTIN
M9929-25MG	04061834064640
M9929-100MG	04061834064633
M9929-500MG	04061834064657

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

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甲氨蝶呤

meets USP testing specifications

选择尺寸

关于此项目

主要文件

属性

biological source

Quality Level

agency

assay

form

storage condition

technique(s)

impurities

color

mp

solubility

antibiotic activity spectrum

application(s)

mode of action

storage temp.

SMILES string

InChI

InChI key

Gene Information

说明

Application

Biochem/physiol Actions

Other Notes

安全信息

pictograms

signalword

hcodes

pcodes

Hazard Classifications

存储类别

flash_point_f

flash_point_c

ppe

文件

分析证书(COA)

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