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生物来源
synthetic
质量水平
Agency
USP/NF
meets USP testing specifications
检测方案
98.0-102.0%
形式
powder
储存条件
(Tightly closed. Dry. Keep in a well-ventilated place. )
技术
activity assay: suitable
cell based assay: suitable
杂质
≤0.1% Residue on ignition (Ash)
≤12.0% water (Karl Fischer)
颜色
yellow to orange-yellow
mp
185-204 °C (365 - 399 °F)
溶解性
water: insoluble
抗生素抗菌谱
parasites
应用
advanced drug delivery
metabolomics
microbiology
作用机制
DNA synthesis
储存温度
−20°C
SMILES字符串
[H]O[H].CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O
InChI
1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);1H2/t13-;/m0./s1
InChI key
FPJYMUQSRFJSEW-ZOWNYOTGSA-N
基因信息
human ... DHFR(1719) , DHFRP1(573971) , FPGS(2356) , SLC19A1(6573) , TYMS(7298)
mouse ... Dhfr(13361)
rat ... Dhfr(24312)
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警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
从最新的版本中选择一种：
分析证书(COA)
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What is the solubility of Methotrexate, Product M9929?
Methotrexate is practically insoluble in water. It does dissolve in solutions of mineral acids (such as HCl) and in dilute solutions of alkali hydroxides. A solution can be prepared in 0.1 M sodium hydroxide at 20 mg/ml (may require some heating).
Can Product M9929, Methotrexate, be stored?
Alkaline stock solutions can decompose. It is best to prepare stock solutions in a minimal amount of of 1 M sodium hydroxide, then dilute with saline or medium. Solutions can be stored at -20°C for about one month. Solutions can be stored for about 1 week at 2-8°C.
How can I sterilize Product M9929, Methotrexate solutions?
Solutions can be sterile filtered.
What does the description of "meets USP testing specification" signify?
The product has been tested according to the specifications in the monograph of the United States Pharmacopoeia.
Has Product M9929, Methotrexate, been tested for cell culture applications?
Product M9929 has not been cell culture tested. Product M8407, Methotrexate hydrate, has been both mammalian and insect cell culture tested and is recommended to use for these applications.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
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