N5410
烟酸
meets USP testing specifications
别名:
3-吡啶甲酸, 吡啶-3-羧酸, 尼亚生, 抗糙皮病因子, 维生素 B3
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关于此项目
经验公式（希尔记法）:
C6H5NO2
化学文摘社编号:
分子量:
123.11
UNSPSC Code:
12352106
NACRES:
NA.21
PubChem Substance ID:
EC Number:
200-441-0
Beilstein/REAXYS Number:
109591
MDL number:
产品名称
烟酸, meets USP testing specifications
InChI key
PVNIIMVLHYAWGP-UHFFFAOYSA-N
InChI
1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
SMILES string
OC(=O)c1cccnc1
biological source
synthetic (organic)
agency
USP/NF
meets USP testing specifications
assay
99.0-101.0% dry basis
form
powder
color
white
mp
236-239 °C (lit.)
application(s)
pharmaceutical (small molecule)
Quality Level
Gene Information
human ... CYP1A2(1544)
rat ... Chrnb2(54239)
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Application
Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity.
Biochem/physiol Actions
Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia. It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides. Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease Deficiency also impacts DNA repair and also leads to skin and gastrointestinal disorder, pellagra. Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels.
General description
Nicotinic acid, also referred to as niacin or as vitamin B3, is a water-soluble vitamin. Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
379.4 °F - closed cup
flash_point_c
193 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
Effect of pO2 on antitumor drug cytotoxicity on MDR and non-MDR variants selected from the LoVo metastatic colon carcinoma cell line
Lelong-Rebel I, et al.
Anticancer Research, 28(1A), 55-68 (2008)
Pellagra: a non-eradicated old disease
Savvidou S
Clinics and practice, 4(1) (2014)
Niacin deficiency delays DNA excision repair and increases spontaneous and nitrosourea-induced chromosomal instability in rat bone marrow
Kostecki LM
Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis, 625(1-2), 50-61 (2007)
Nicotinic acid: an old drug with a promising future
Bodor ET and Offermanns S
British Journal of Pharmacology, 153(S1), S68-S75 (2008)
Nicotinic acid: a lipid-lowering agent with unrealized potential
Aboulsoud SH
The Egyptian Journal of Internal Medicine, 26(1), 1-1 (2014)
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