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Merck
CN

N6160

Sigma-Aldrich

新生霉素 钠

meets USP testing specifications

别名:

新生霉素 钠盐

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关于此项目

经验公式（希尔记法）:
C31H35N2NaO11
化学文摘社编号:
1476-53-5
分子量:
634.61
Beilstein:
3892910
EC 号:
216-023-6
UNSPSC代码:
51286504
PubChem化学物质编号:
24897774
NACRES:
NA.76

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Agency

USP/NF
meets USP testing specifications

质量水平

200

表单

powder

抗生素抗菌谱

Gram-positive bacteria

应用

pharmaceutical (small molecule)

作用机制

DNA synthesis | interferes
enzyme | inhibits

储存温度

2-8°C

SMILES字符串

[Na+].CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3C([O-])=C(NC(=O)c4ccc(O)c(C\C=C(\C)C)c4)C(=O)Oc3c2C)OC1(C)C

InChI

1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1

InChI key

AXOUUAINTJNFRS-UHFFFAOYSA-N

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相关类别

一般描述

Chemical structure: coumarin-glycoside

应用

For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.

生化/生理作用

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.
Antimicrobial spectrum: Gram-positive bacterial.

其他说明

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302,H317,H319

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000484179
0000484179
0000435254
0000435254
0000381696

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Liang Zhang et al.
Journal of proteome research, 11(4), 2581-2593 (2012-03-15)
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes in which hyperglycemia-induced mitochondrial dysfunction and enhanced oxidative stress contribute to sensory neuron pathology. KU-32 is a novobiocin-based, C-terminal inhibitor of the molecular chaperone, heat shock protein 90 (Hsp90). KU-32
Kirsten J Meyer et al.
The Journal of infectious diseases, 208(3), 489-499 (2013-05-01)
African sleeping sickness, caused by the protozoan parasite Trypanosoma brucei, is universally fatal if untreated, and current drugs are limited by severe toxicities and difficult administration. New antitrypanosomals are greatly needed. Heat shock protein 90 (Hsp90) is a conserved and
Pinanong Na Phatthalung et al.
BMC complementary and alternative medicine, 12, 56-56 (2012-04-28)
Acinetobacter baumannii is well-recognized as an important nosocomial pathogen, however, due to their intrinsic resistance to several antibiotics, treatment options are limited. Synergistic effects between antibiotics and medicinal plants, particularly their active components, have intensively been studied as alternative approaches.
Matjaž Brvar et al.
Journal of medicinal chemistry, 55(14), 6413-6426 (2012-06-27)
Bacterial DNA gyrase is a well-established and validated target for the development of novel antibacterials. Starting from the available structural information about the binding of the natural product inhibitor, clorobiocin, we identified a novel series of 4'-methyl-N(2)-phenyl-[4,5'-bithiazole]-2,2'-diamine inhibitors of gyrase
Patricia L Taylor et al.
ACS chemical biology, 7(9), 1547-1555 (2012-06-16)
Multi-drug-resistant infections caused by Gram-negative pathogens are rapidly increasing, highlighting the need for new chemotherapies. Unlike Gram-positive bacteria, where many different chemical classes of antibiotics show efficacy, Gram-negatives are intrinsically insensitive to many antimicrobials including the macrolides, rifamycins, and aminocoumarins
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实验方案

Salmonella Detection Procedure (EN ISO 6579-1)

EN ISO 6579-1 standard specifies detection of Salmonella spp. in human consumption, animal feed, and environmental samples.

关于食品链沙门氏菌检测的ISO 6579-1标准

规定了在食品生产链中检测沙门氏菌水平的方法。

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