N7889
尼麦角林
analytical standard, for drug analysis
别名:
5-溴烟酸 10-甲氧基-1,6-二甲基麦角灵-8-甲酯
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关于此项目
经验公式（希尔记法）:
C24H26BrN3O3
化学文摘社编号:
分子量:
484.39
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
analytical standard
质量水平
方案
≥97% (TLC)
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
forensics and toxicology
pharmaceutical (small molecule)
veterinary
包装形式
neat
储存温度
2-8°C
SMILES字符串
[H][C@@]12Cc3cn(C)c4cccc(c34)[C@]1(C[C@@H](COC(=O)c5cncc(Br)c5)CN2C)OC
InChI
1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1
InChI key
YSEXMKHXIOCEJA-FVFQAYNVSA-N
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一般描述
Nicergoline is an ergot derivative, which may be used in the treatment of affective, cognitive and behavioral disorders seen in older people. It is an α -adrenergic antagonist that may be used for companion animals like cats and dogs to treat, behavioral disorders, problems with aging, excessive vocaliztion and restessness.
应用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
生化/生理作用
大脑和周边血管舒张剂
Maddison.EJ, et al.
Small Animal Clinical Pharmacology (2008)
Nicergoline for dementia and other age associated forms of cognitive impairment
MF and LF
Cochrane database of systematic reviews (Online), 2001-2001 null
Su-Young Kim et al.
Current eye research, 36(1), 29-33 (2010-12-23)
We wanted to investigate the effect of nicergoline on corneal nerve regeneration in rat corneas after photorefractive keratectomy (PRK). Twenty Sprague-Dawley male rats were divided into two groups, the control group and the group that had been treated with nicergoline
Tetsuya Mizuno et al.
Brain research, 1066(1-2), 78-85 (2005-12-06)
We examined the neuroprotective role of nicergoline in neuron-microglia or neuron-astrocytes co-cultures. Nicergoline, an ergoline derivative, significantly suppressed the neuronal cell death induced by co-culture with activated microglia or astrocytes stimulated with lipopolysaccharide (LPS) and interferon (IFN)-gamma. To elucidate the
V Vitton et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 18(11), 1031-1040 (2006-10-17)
A pontine centre located near the micturition centre controlling external anal sphincter (EAS) motility via noradrenergic neurones has been described in cats. The aim of this study was to determine (i) whether a similar centre controls EAS motility in humans
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