N9007
诺司卡品 盐酸盐 水合物
analytical standard
别名:
那可汀 盐酸盐
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关于此项目
经验公式（希尔记法）:
C22H23NO7 · HCl · xH2O
化学文摘社编号:
分子量:
449.88 (anhydrous basis)
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
213-014-9
MDL number:
InChI key
ZYGSNVAGWKWKKI-WCRQIBMVSA-N
InChI
1S/C22H23NO7.ClH.H2O/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18;;/h5-6,9,17-18H,7-8,10H2,1-4H3;1H;1H2/t17-,18+;;/m1../s1
SMILES string
O.Cl.COc1ccc2C(OC(=O)c2c1OC)C3N(C)CCc4cc5OCOc5c(OC)c34
grade
analytical standard
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
221-223 °C (lit.)
application(s)
food and beverages
format
neat
storage temp.
2-8°C
Quality Level
Application
Noscapine hydrochloride hydrate may be used as a reference standard in the determination of noscapine hydrochloride in the synthetic binary mixtures like chlorpheniramine-noscapine and chlorpheniramine-guaiphenesin using derivative spectrophotometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral - STOT SE 3
target_organs
Central nervous system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
Rapid and accurate determination of chlorpheniramine maleate, noscapine hydrochloride and guaiphenesin in binary mixtures by derivative spectrophotometry.
Pappano B N, et al.
Talanta, 44(4), 633-639 (1997)
Patricia López et al.
Food chemistry, 242, 443-450 (2017-10-19)
A straightforward method to determine the content of six opium alkaloids (morphine, codeine, thebaine, noscapine, papaverine and narceine) in poppy seeds and bakery products was developed and validated down to a limit of quantification (LOQ) of 0.1mg/kg. The method was
Ana Amaral et al.
International journal of molecular sciences, 22(10) (2021-06-03)
Endometrosis is a reproductive pathology that is responsible for mare infertility. Our recent studies have focused on the involvement of neutrophil extracellular traps enzymes, such as elastase (ELA), in the development of equine endometrosis. Noscapine (NOSC) is an alkaloid derived
Ana Amaral et al.
Life (Basel, Switzerland), 11(10) (2021-10-24)
Cathepsin G (CAT) is a protease released by neutrophils when forming neutrophil extracellular traps that was already associated with inducing type I collagen (COL1) in equine endometrium in vitro. Endometrosis is a fibrotic condition mainly characterized by COL1 deposition in
Srinivasa M Sammeta et al.
Pharmaceutical development and technology, 20(2), 169-175 (2013-11-14)
The main objective of the present study was to develop formulations of noscapine hydrochloride hydrate with enhanced solubility and bioavailability using co-solvent- and cyclodextrin-based approaches. Different combinations of co-solvents, which were selected on the basis of high-throughput solubility screening, were
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