O5380
奥昔卡因
analytical standard
别名:
2-羟乙基亚氨基双(N-[α,α-二甲基苯乙基]-N-甲基乙酰胺), 阿塞赛因
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关于此项目
经验公式（希尔记法）:
C28H41N3O3
化学文摘社编号:
分子量:
467.64
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
204-780-5
MDL number:
InChI key
FTLDJPRFCGDUFH-UHFFFAOYSA-N
InChI
1S/C28H41N3O3/c1-27(2,19-23-13-9-7-10-14-23)29(5)25(33)21-31(17-18-32)22-26(34)30(6)28(3,4)20-24-15-11-8-12-16-24/h7-16,32H,17-22H2,1-6H3
SMILES string
CN(C(=O)CN(CCO)CC(=O)N(C)C(C)(C)Cc1ccccc1)C(C)(C)Cc2ccccc2
grade
analytical standard
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
Quality Level
General description
Oxethazaine is a topical anesthetic, administered as an antacid for treating pain associated with duodenal ulcer, esophagitis and gastritis.
Application
Oxethazaine may be used as an analytical reference standard for the quantification of the analyte in biological samples using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
G J Anthone et al.
American journal of surgery, 163(1), 150-156 (1992-01-01)
A signal for meal-induced absorption originates from the small intestine and is transmitted to a luminally excluded segment of the proximal jejunum (Thiry-Vella [TV] fistula). Using intraluminal topical anesthesia with oxethazaine, this study assessed the role of intestinal neural pathways
A Zanni et al.
Current medical research and opinion, 10(2), 128-134 (1986-01-01)
A double-blind study was carried out in 40 patients with typical ulcer pain and suffering from gastric or duodenal ulcer to compare the pain-relieving efficacy of oxethazaine/magnesium and aluminium hydroxide mixture with that of the antacid combination alone. Patients took
Yasusuke Masuda
Journal of pharmacological sciences, 100(3), 167-174 (2006-03-07)
The liver has an intricate microvascular system that allows homogenous perfusion throughout the organ. However, the regulatory mechanisms of intrahepatic circulation are still unclear, and the effects of drugs on this system have rarely been reported. Oxethazaine, a topical anesthetic
[Resorption of cyclosporin administered by oral route to renal transplant patients. Influence of breakfast and an antacid drug].
F Penouil et al.
Therapie, 43(1), 15-19 (1988-01-01)
T Takagi et al.
The American journal of physiology, 255(4 Pt 1), G522-G528 (1988-10-01)
Celiac and superior mesenteric arterial blood flows were measured simultaneously in conscious beagle dogs. The responses to food were completely different between the two arteries. Celiac flow increased quickly to 180-200% of the control 2 min after food but started
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