InChI key
FTLDJPRFCGDUFH-UHFFFAOYSA-N
InChI
1S/C28H41N3O3/c1-27(2,19-23-13-9-7-10-14-23)29(5)25(33)21-31(17-18-32)22-26(34)30(6)28(3,4)20-24-15-11-8-12-16-24/h7-16,32H,17-22H2,1-6H3
SMILES string
CN(C(=O)CN(CCO)CC(=O)N(C)C(C)(C)Cc1ccccc1)C(C)(C)Cc2ccccc2
grade
analytical standard
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
Quality Level
General description
Oxethazaine is a topical anesthetic, administered as an antacid for treating pain associated with duodenal ulcer, esophagitis and gastritis.
Application
Oxethazaine may be used as an analytical reference standard for the quantification of the analyte in biological samples using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
A Pap et al.
Acta medica Academiae Scientiarum Hungaricae, 37(3), 305-313 (1980-01-01)
The effect of submaximal doses of intravenous atropine and their combination with topical anaesthesia of the intestine by oxethazaine-HCl was investigated in conscious rats. I. Basal water, bicarbonate and protein secretion were significantly augmented after diversion of pancreatic juice. On
The abuse potential of oxethazaine: effects of oxethazaine on drug-seeking behavior and analysis of its metabolites in plasma and hair in animal models
Lee Y-S, et al.
Pharmacology, Biochemistry, and Behavior, 105(3), 98-104 (2013)
Y Yamazaki
Digestive diseases and sciences, 27(9), 821-827 (1982-09-01)
The mechanism by which oxethazaine inhibits hydrochloric acid stimulation of pancreatic secretion and the endogenous release of secretin was studied in six dogs prepared with pancreatic and gastric fistulae. Oxethazaine reduced both pancreatic secretion and plasma secretin concentration evoked by
Yasusuke Masuda et al.
Biochemical pharmacology, 64(4), 677-687 (2002-08-09)
There have been few reports on the mechanism(s) of action of oxethazaine (OXZ) despite its potent local anesthetic action. Generally, local anesthetics (LAs) not only inhibit Na(+) channels but also affect various membrane functions. In the present study, using PC12
M K Barry et al.
The Journal of surgical research, 58(4), 425-431 (1995-04-01)
The ingestion of a meal stimulates absorption from the jejunal lumen and is dependent on intact neural pathways. Few studies of ileal absorptive responses to a meal have been performed. This study tested two hypotheses: (1) a meal stimulates ileal
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持