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文件

安全信息

P0300000

扑热息痛

European Pharmacopoeia (EP) Reference Standard

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别名:
对乙酰氨基酚, 4′-羟基乙酰苯胺, 4-乙酰氨基酚, N-(4-羟基苯基)乙酰胺, N-乙酰基-4-氨基苯酚, APAP, 扑热息痛
线性分子式:
CH3CONHC6H4OH
CAS号:
103-90-2
分子量:
151.16
Beilstein:
2208089
EC 号:
203-157-5
MDL编号:
MFCD00002328
PubChem化学物质编号:
329820028
NACRES:
NA.24

等级

pharmaceutical primary standard

描述

API family: acetaminophen

API类

paracetamol, acetaminophen

制造商/商品名称

EDQM

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

168-172 °C (lit.)

应用

pharmaceutical (small molecule)

格式

neat

SMILES字符串

CC(=O)Nc1ccc(O)cc1

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

InChI key

RZVAJINKPMORJF-UHFFFAOYSA-N

基因信息

human ... FAAH(2166) , PTGS1(5742) , PTGS2(5743) , TRPV1(7442)

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相关类别

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Paracetamol EP reference standard, intended for use only as specifically prescribed in the European Pharmacopoeia.
镇痛剂。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

相关产品

产品编号
说明
价格

PHR1005

对乙酰氨基酚, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1148

对乙酰氨基酚相关化合物K, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1149

对乙酰氨基酚相关化合物J, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1150

对乙酰氨基酚相关化合物F, Pharmaceutical Secondary Standard; Certified Reference Material

1003009

对乙酰氨基酚, United States Pharmacopeia (USP) Reference Standard

1021204

4-氨基苯酚, United States Pharmacopeia (USP) Reference Standard

PHR1225

3-氨基苯酚, Pharmaceutical Secondary Standard; Certified Reference Material

1003010

Acetaminophen Related Compound A, United States Pharmacopeia (USP) Reference Standard

PHR1531

对乙酰氨基酚相关化合物C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1530

对乙酰氨基酚相关化合物D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1612

对乙酰氨基酚相关化合物A, Pharmaceutical Secondary Standard; Certified Reference Material

1003027

Acetaminophen Related Compound B, United States Pharmacopeia (USP) Reference Standard

1003042

乙酰苯胺, United States Pharmacopeia (USP) Reference Standard

1003100

4'-氯乙酰苯胺, United States Pharmacopeia (USP) Reference Standard

1003031

2-乙酰胺基苯酚, United States Pharmacopeia (USP) Reference Standard

PHR1642

对乙酰氨基酚相关化合物B, Pharmaceutical Secondary Standard; Certified Reference Material

1003064

4-硝基苯酚, United States Pharmacopeia (USP) Reference Standard

1026004

3-氨基苯酚, United States Pharmacopeia (USP) Reference Standard

Y0001781

设备鉴定用扑热息痛, European Pharmacopoeia (EP) Reference Standard

PHR1745

4-氨基苯酚, Pharmaceutical Secondary Standard; Certified Reference Material

BP371

扑热息痛, British Pharmacopoeia (BP) Reference Standard

Y0001945

对乙酰氨基酚杂质J, European Pharmacopoeia (EP) Reference Standard

Y0001955

对乙酰氨基酚杂质K, European Pharmacopoeia (EP) Reference Standard

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

364.3 °F - Pensky-Martens closed cup

闪点(°C)

184.6 °C - Pensky-Martens closed cup

法规信息

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S M de Morais et al.
Gastroenterology, 102(2), 577-586 (1992-02-01)
Gilbert's syndrome occurs in 5%-7% of the human population and is caused by an inherited deficiency in the glucuronidation of endogenous bilirubin, resulting in its accumulation and jaundice. The authors of the present study have previously shown that rats with
Karel Allegaert et al.
Archives of disease in childhood, 98(6), 462-466 (2013-04-23)
There remains a need for alternative medical treatments for patent ductus arteriosus (PDA) closure in extreme preterm neonates because of therapeutic failure and adverse effects associated with non-selective cyclo-oxygenase inhibitors. Reports of an association between paracetamol exposure and PDA closure
Garry G Graham et al.
Drug safety, 28(3), 227-240 (2005-03-01)
The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported
Mitchell R McGill et al.
Pharmaceutical research, 30(9), 2174-2187 (2013-03-07)
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver. The first studies of APAP metabolism and activation were published more than 40 years ago.
Garry G Graham et al.
Inflammopharmacology, 21(3), 201-232 (2013-05-31)
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. Paracetamol is, on average, a weaker analgesic than NSAIDs or COX-2 selective
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