P0597
毛果芸香碱 硝酸酯
meets USP testing specifications
别名:
毛果芸香碱 硝酸盐
Agency
USP/NF
meets USP testing specifications
质量水平
表单
crystals
应用
pharmaceutical (small molecule)
SMILES字符串
O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C
InChI
1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1
InChI key
PRZXEPJJHQYOGF-GNAZCLTHSA-N
基因信息
human ... CHRM1(1128), CHRM3(1131)
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生化/生理作用
非选择性毒蕈碱型乙酰胆碱受体激动剂。
非选择性毒蕈碱型乙酰胆碱受体激动剂；用于建立癫痫的实验模型。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2
储存分类代码
5.1B - Oxidizing hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
Shuo-Bin Jou et al.
Seizure, 22(3), 221-229 (2013-01-15)
Bilateral electrical stimulation of anterior nuclei of thalamus (ANT) has shown promising effects on epileptic seizures. However, bilateral implantation increases the risk of surgical complications and side effects. This study was undertaken to access the effectiveness of a stimulation paradigm
Kathleen Heng et al.
Epilepsia, 54(9), 1535-1541 (2013-07-16)
The role of granule cell axon (mossy fiber) sprouting in temporal lobe epileptogenesis is unclear and controversial. Rapamycin suppresses mossy fiber sprouting, but its reported effects on seizure frequency are mixed. The present study used high-dose rapamycin to more completely
Manuela Mazzuferi et al.
Annals of neurology, 74(4), 560-568 (2013-05-21)
Epigenetic mechanisms involved in transcriptional regulation of multiple molecular pathways are potentially attractive therapeutic interventions for epilepsy, because single target therapies are unlikely to provide both anticonvulsant and disease-modifying effects. A selection of epilepsy-related gene expression data sets were retrieved
Jiandong Yu et al.
Journal of neurophysiology, 109(7), 1746-1763 (2013-01-18)
Temporal lobe epilepsy is associated with loss of interneurons and inhibitory dysfunction in the dentate gyrus. While status epilepticus (SE) leads to changes in granule cell inhibition, whether dentate basket cells critical for regulating granule cell feedforward and feedback inhibition
Jerome Clasadonte et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(43), 17540-17545 (2013-10-09)
Astrocytes modulate neuronal activity, synaptic transmission, and behavior by releasing chemical transmitters in a process termed gliotransmission. Whether this process impacts epilepsy in vivo is not known. We show that genetic impairment of transmitter release from astrocytes by the expression
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