P5654
吡罗昔康
≥98% (TLC)
别名:
2-甲基-4-羟基-N-(2-吡啶基)-2H-1,2-苯并噻嗪-3-甲酰胺-1,1-二氧化物
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关于此项目
经验公式（希尔记法）:
C15H13N3O4S
化学文摘社编号:
分子量:
331.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
252-974-3
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥98% (TLC)
form
powder
storage temp.
2-8°C
SMILES string
CN1C(C(=O)Nc2ccccn2)=C(O)c3ccccc3S1(=O)=O
InChI
1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)
InChI key
QYSPLQLAKJAUJT-UHFFFAOYSA-N
Gene Information
human ... PTGS1(5742), PTGS2(5743)
rat ... Alox5(25290)
Application
吡罗昔康已用于：
- 诱发小鼠结肠炎
- 作为非类固醇抗炎药，提高白介素-10(IL-10)敲除小鼠对肠道损伤的敏感性
- 研究其作为化学预防试剂和阳性对照，对小鼠小肠肿瘤生长的影响
Biochem/physiol Actions
吡罗昔康(Piroxicam)是非类固醇抗炎药(NSAID)。具有镇痛活性，对风湿病有治疗作用。
环加氧酶抑制剂。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - STOT RE 2 Oral
target_organs
Gastrointestinal tract
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling
Lang M, et al.
Molecular Cancer, 12(1), 41-41 (2013)
Jiawei Guo et al.
Cell reports. Medicine, 4(1), 100881-100881 (2023-01-06)
Systematic bone loss is commonly complicated with inflammatory bowel diseases (IBDs) with unclear pathogenesis and uncertain treatment. In experimental colitis mouse models established by dextran sulfate sodium and IL-10 knockout induced with piroxicam, bone mass and quality are significantly decreased.
Michaela Lang et al.
Molecular cancer, 12(1), 41-41 (2013-05-15)
Patients with familial adenomatous polyposis (FAP) are at increased risk for the development of colorectal cancer. Surgery and chemoprevention are the most effective means to prevent cancer development. Thymoquinone (TQ) is considered the main compound of the volatile Nigella sativa
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P5654-25G-A | 04061838174956 |
| P5654-5G | 04061833429365 |
| P5654-10G | 04061834392149 |
| P5654-1G | 04061834392156 |
| P5654-5G-A | 04061834392163 |