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Merck
CN

P7003

哌嗪 六水合物

analytical standard

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关于此项目

经验公式(希尔记法):
C4H10N2 · 6H2O
化学文摘社编号:
分子量:
194.23
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
203-808-3
Beilstein/REAXYS Number:
4455527
MDL number:
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InChI key

AVRVZRUEXIEGMP-UHFFFAOYSA-N

InChI

1S/C4H10N2.6H2O/c1-2-6-4-3-5-1;;;;;;/h5-6H,1-4H2;6*1H2

SMILES string

[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].C1CNCCN1

grade

analytical standard

vapor pressure

0.8 mmHg ( 20 °C)

assay

≥99% (TLC)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

bp

145-156 °C (lit.)

Quality Level

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

General description

六水合哌嗪可作为标准品,通过比色法对药物制剂中哌嗪进行测定。

Application

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pictograms

Health hazardCorrosion

signalword

Danger

Hazard Classifications

Repr. 2 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

存储类别

8A - Combustible corrosive hazardous materials

wgk

WGK 1

flash_point_f

190.4 °F - closed cup

flash_point_c

88 °C - closed cup

法规信息

危险化学品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Colorimetric determination of piperazine in pharmaceutical formulations
Dessouky M Y and Ismaiel A S.
Analyst, 99(1181), 482-486 (1974)
Juneha Bak et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 36(10), 1269-1274 (2020-06-23)
Sulfated saccharides exhibit diverse physiological activities, but a lack of any convenient assay hinders their evaluation. Herein, an assay for the analysis of sulfated saccharides is described using 1H nuclear magnetic resonance (NMR) spectroscopy by employing ligands that can form
P Krishnan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 102, 379-385 (2012-12-12)
Monohydrate piperazine hydrogen phosphate (MPHP), a semi organic nonlinear optical material has been synthesized and single crystals were grown from aqueous solution by slow evaporation technique. Single crystal X-ray diffraction study on grown crystal reveals that they belong to monoclinic
William Conway et al.
The journal of physical chemistry. A, 117(5), 806-813 (2013-01-05)
Piperazine (PZ) is widely recognized as a promising solvent for postcombustion capture (PCC) of carbon dioxide (CO(2)). In view of the highly conflicting data describing the kinetic reactions of CO(2)(aq) in piperazine solutions, the present study focuses on the identification
Yuji Nakamura et al.
Bioorganic & medicinal chemistry letters, 22(14), 4561-4566 (2012-06-26)
Introduction of the 2,2-dimethyl-4-phenylpiperazin-5-one scaffold into the P(3)-P(1) portion of the (2S,4S,5S)-5-amino-6-dialkylamino-4-hydroxy-2-isopropylhexanamide backbone dramatically increased the renin inhibitory activity without using the interaction to the S(3)(sp) pocket. Compound 31 exhibited >10,000-fold selectivity over other human proteases, and 18.5% oral bioavailability

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