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Merck
CN

P9672

普罗布考

analytical standard

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关于此项目

经验公式（希尔记法）:
C31H48O2S2
化学文摘社编号:
23288-49-5
分子量:
516.84
NACRES:
NA.24
PubChem Substance ID:
329820354
UNSPSC Code:
41116107
EC Number:
245-560-9
MDL number:
MFCD00079281

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InChI key

FYPMFJGVHOHGLL-UHFFFAOYSA-N

InChI

1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3

SMILES string

CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

200

Gene Information

human ... ABCA1(19), IL1B(3553), IL6(3569), TNF(7124)

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相关类别

General description

Probucol is a diphenolic compound possessing antioxidant and anti-inflammatory properties. It is commercially used as a lipid lowering drug, which helps in reducing the total plasma cholesterol, low density lipoprotein cholesterol (LDL) and high density lipoprotein cholesterol (HDL).

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

提高 HDL 相关胆固醇酯的选择性摄取

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000512647
0000512647
0000492794
0000492794
0000460435

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Eduardo Luiz Gasnhar Moreira et al.
Neuroscience letters, 541, 193-198 (2013-03-09)
Epidemiological studies indicate that high midlife plasma cholesterol levels increases the risk of Alzheimer's disease. Moreover, middle-aged familial hypercholesterolemia (FH) subjects show a particularly high incidence of mild cognitive impairments (MCI). These evidence points to hypercholesterolemia as one of the
Chang-Jiang Ge et al.
Chinese medical journal, 125(14), 2472-2476 (2012-08-14)
The plasma cystatin C concentration (PcyC) has been demonstrated to have prognostic value in acute coronary syndrome, but the study of PcyC in patients with borderline coronary lesions is limited. Moreover, the effects of atorvastatin and probucol on PcyC and
Jonathan Watt et al.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 81(4), 698-708 (2012-05-15)
The aim of this study was to assess the efficacy of stent-based delivery of succinobucol alone and in combination with rapamycin in a porcine coronary model. Current drugs and polymers used to coat coronary stents remain suboptimal in terms of
Rong Wu et al.
Digestive diseases and sciences, 58(1), 163-171 (2012-08-11)
We sought to evaluate the effects of probucol on steatohepatitis and associated molecular mechanisms in a rat model of nonalcoholic steatohepatitis (NASH) induced by high-fat diet (HFD). Forty male rats weighing 100-120 g were randomly assigned to the following treatments (n = 10
Ryusuke Takechi et al.
Clinical and experimental pharmacology & physiology, 40(1), 45-52 (2012-11-22)
Dysfunction of the blood-brain barrier (BBB) is an early pathological feature of vascular dementia and Alzheimer's disease (AD) and is triggered by inflammatory stimuli. Probucol is a lipid-lowering agent with potent anti-oxidant properties once commonly used for the treatment of
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商品

Cholesterol Transport

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

Cholesterol Transport

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

胆固醇的运输

由于胆固醇是水不溶性分子，必须包装后才能在血浆中运输。包装胆固醇、胆固醇酯和甘油三酯以便运输的颗粒称为脂蛋白。

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