PHR1016
马来酸氯苯那敏
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
(±)-氯苯那敏 马来酸盐
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关于此项目
经验公式（希尔记法）:
C16H19ClN2 · C4H4O4
化学文摘社编号:
分子量:
390.86
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
204-037-5
MDL number:
产品名称
马来酸氯苯那敏, Pharmaceutical Secondary Standard; Certified Reference Material
application(s)
pharmaceutical (small molecule)
InChI key
DBAKFASWICGISY-BTJKTKAUSA-N
InChI
1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES string
CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. C1800000
traceable to USP 1123000
API family
chlorpheniramine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
130-135 °C (lit.)
format
neat
storage temp.
2-30°C
Quality Level
Gene Information
human ... HRH1(3269)
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Biochem/physiol Actions
H 1 组胺受体拮抗剂。
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Application
Chlorpheniramine Maleate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Chlorpheniramine Maleate is an H1-receptor antagonist drug grouped under the class of antihistaminic compounds.
Chlorpheniramine Maleate is an H1-receptor antagonist drug grouped under the class of antihistaminic compounds.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0771 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Poly (ethyleneglycol) column for the determination of acetaminophen, phenylephrine and chlorpheniramine in pharmaceutical formulations
Garcia A, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 785(2), 237-243 (2003)
Normal-phase LC method for simultaneous analysis of pseudophedrine hydrochloride, dextromethorphan hydrobromide, chlorpheniramine maleate, and paracetamol in tablet formulations
Al-Rimawi F
Saudi Pharmaceutical Journal : SPJ : The Official Publication of the Saudi Pharmaceutical Society, 18(2), 103-106 (2010)
New approaches with two cyano columns to the separation of acetaminophen, phenylephrine, chlorpheniramine and related compounds
Olmo B, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 817(2), 159-165 (2005)
CE versus HPLC for the dissolution test in a pharmaceutical formulation containing acetaminophen, phenylephrine and chlorpheniramine
Marin A and Barbas C
Journal of Pharmaceutical and Biomedical Analysis, 35(4), 769-777 (2004)
Validation of a HPLC quantification of acetaminophen, phenylephrine and chlorpheniramine in pharmaceutical formulations: capsules and sachets.
Marin A, et al.
Journal of Pharmaceutical and Biomedical Analysis, 29(4), 701-714 (2002)
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