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Merck
CN

PHR1029

D-α-生育酚琥珀酸酯

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

D-α-生育酚琥珀酸酯, 维生素 E 琥珀酸酯

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关于此项目

经验公式（希尔记法）:
C33H54O5
化学文摘社编号:
4345-03-3
分子量:
530.78
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823059
EC Number:
224-403-8
Beilstein/REAXYS Number:
4038233
MDL number:
MFCD00072055

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产品名称

D-α-生育酚琥珀酸酯, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C33H54O5/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-20-33(8)21-19-28-27(7)31(25(5)26(6)32(28)38-33)37-30(36)18-17-29(34)35/h22-24H,9-21H2,1-8H3,(H,34,35)/t23-,24-,33-/m1/s1

InChI key

IELOKBJPULMYRW-NJQVLOCASA-N

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(=O)CCC(O)=O)c(C)c(C)c2O1

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. T1610000
traceable to USP 1667803

API family

tocopherol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Tocopheryl Acid Succinate, a is a derivative of vitamin E and a potent and highly specific anticancer agent known to inhibit the growth of cancer cells.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3258 in the slot below. This is an example certificate only and may not be the lot that you receive.

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Vitamin E succinate induces Fas-mediated apoptosis in estrogen receptor-negative human breast cancer cells
Turley JM, et al.
Cancer Research, 57(5), 881-890 (1997)
Pengfei Xu et al.
Biomaterials, 35(26), 7574-7587 (2014-06-06)
Metastasis is one of the major obstacles for the successful therapy of breast cancer. Although increased candidate drugs targeting cancer metastasis are tested, their clinical translation is limited by either serve toxicity or low efficacy. In present work, a nano-drug
Sindhuri Maddineni et al.
AAPS PharmSciTech, 16(2), 444-454 (2014-11-02)
The objective of the present study was to investigate the effects of processing variables and formulation factors on the characteristics of hot-melt extrudates containing a copolymer (Kollidon® VA 64). Nifedipine was used as a model drug in all of the

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