PHR1156
乙酰柠檬酸三丁酯
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
柠檬酸乙酰基三丁酯
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线性分子式:
CH3CO2C[CO2(CH2)3CH3][CH2CO2(CH2)3CH3]2
化学文摘社编号:
分子量:
402.48
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
201-067-0
Beilstein/REAXYS Number:
2303316
MDL number:
产品名称
乙酰柠檬酸三丁酯, Pharmaceutical Secondary Standard; Certified Reference Material
InChI
1S/C20H34O8/c1-5-8-11-25-17(22)14-20(28-16(4)21,19(24)27-13-10-7-3)15-18(23)26-12-9-6-2/h5-15H2,1-4H3
InChI key
QZCLKYGREBVARF-UHFFFAOYSA-N
SMILES string
CCCCOC(=O)CC(CC(=O)OCCCC)(OC(C)=O)C(=O)OCCCC
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. Y0001055
traceable to USP 1009901
vapor pressure
0.26 psi ( 20 °C)
0.8 psi ( 55 °C)
description
API family: acetyltributyl citrate
API family
acetyltributyl citrate
CofA
current certificate can be downloaded
Quality Level
greener alternative product characteristics
Less Hazardous Chemical Syntheses
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
refractive index
n20/D 1.443 (lit.)
density
1.05 g/mL at 25 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
greener alternative category
storage temp.
2-30°C
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General description
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product is environmentally-benign and can replace highly toxic phthalates in membrane preparation and thus aligns with "Less Hazardous Chemical Syntheses". Click here for more information.
Tributyl 2-acetylcitrate is a hydrophobic biodegradable plasticizer, that is usually synthesized by esterification of citric acid. Pharmaceutically, it is used as an excipient, which is generally applied as a thin film over the tablets or capsules.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Application
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Tributyl 2-acetylcitrate may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by gas chromatography.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA8991 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
422.6 °F - closed cup
flash_point_c
217 °C - closed cup
Study of the migration behavior of acetyl tributyl citrate from PVDC/PVC film into fish fillets as affected by intermediate doses of electron beam radiation
Zygoura PD, et al.
European Food Research and Technology, 232(6), 1017-1025 (2011)
Acetyltributyl Citrate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 35(6)(4), 3833-3834 (2017)
Acetyltributyl Citrate
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 35(6)(4), 5555-5555 (2018)
Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient
Kim H, et al.
Pharmaceutics, 10(4), 177-177 (2018)
Migration of di-(2-ethylhexyl) adipate (DEHA) and acetyl tributyl citrate (ATBC) plasticizers from PVC film into the food stimulant of isooctane: Weichmacherwanderung von Di-(2-ethylhexyl) Adipate (DEHA) und Acetyl Tributyl Zitrate (ATBC) von PVC-Folien in das Genussmittel Isooctan
Lajqi MV, et al.
Materials Science and Engineering Technology, 46(1), 16-23 (2015)
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