PHR1196
呋喃西林
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
5-硝基-2-糠醛半卡巴腙, 5-硝基-2-呋喃甲醛半卡腙, NFZ, 呋喃西林, 硝呋醛
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关于此项目
经验公式（希尔记法）:
C6H6N4O4
化学文摘社编号:
分子量:
198.14
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-443-1
Beilstein/REAXYS Number:
86403
MDL number:
InChI
1S/C6H6N4O4/c7-6(11)9-8-3-4-1-2-5(14-4)10(12)13/h1-3H,(H3,7,9,11)/b8-3+
InChI key
IAIWVQXQOWNYOU-FPYGCLRLSA-N
SMILES string
NC(=O)N\N=C\c1ccc(o1)[N+]([O-])=O
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. N0950000, traceable to USP 1465004
API family
nitrofurazone
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
242-244 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
Nitrofurazone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by DC polarography, chromatography and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0296 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Warning
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Repr. 2 - Skin Sens. 1 - STOT RE 2
target_organs
male reproductive organs
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Electrochemical reduction of nitrofurazone and its determination in pharmaceutical dosage forms by Dc polarography
Mishra AK and Gode KD
Analyst, 110(11), 1373-1376 (1985)
Inclusion compounds in pharmaceutical analysis II: Assay of a cream following chemical dehydration
Hays SE and Grady LT
Journal of Pharmaceutical Sciences, 60(2), 295-298 (1971)
Investigating the potential of non-thermal microwave as a novel skin penetration enhancement method.
Hamid R Moghimi et al.
International journal of pharmaceutics, 401(1-2), 47-50 (2010-09-22)
Microwaves (MW), a part of the electromagnetic spectrum at 0.3-300GHz, affect human body in different ways through its thermal and athermal effects, including fluidization of cell membranes and liquid crystalline systems. Due to presence of such structures in skin barrier
Man Chin Chung et al.
Current pharmaceutical design, 17(32), 3515-3526 (2011-11-15)
In therapeutics research, the nitro compounds are part of an important group of drugs with multiple pharmacological activities. However, in drug design, the inclusion of a nitro group in a molecule changes the physico-chemical and electronic properties and is associated
James R Johnson et al.
Antimicrobial agents and chemotherapy, 56(9), 4969-4972 (2012-07-04)
Two marketed antimicrobial-coated Foley catheters were compared for in vitro diffusible and contact-dependent inhibition of 11 urinary tract infection-associated microorganisms in an adherence-biofilm assay. Nitrofurazone-coated catheters significantly outperformed silver alloy-coated catheters for inhibitory activity, according to both inoculum broth and
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