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PHR1197

5H-二苯并[b,f]氮杂

Name: 5H-二苯并[b,f]氮杂
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:

卡马西平相关化合物B, 亚氨基芪

经验公式（希尔记法）:

C₁₄H₁₁N

CAS号:

256-96-2

分子量:

193.24

Beilstein:

1343358

EC 号:

205-970-0

MDL编号:

MFCD00005071

PubChem化学物质编号:

329823205

NACRES:

NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to USP 1093023

API family

carbamazepine, oxcarbazepine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

196-199 °C (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES string

N1c2ccccc2C=Cc3ccccc13

InChI

1S/C14H11N/c1-3-7-13-11(5-1)9-10-12-6-2-4-8-14(12)15-13/h1-10,15H

InChI key

LCGTWRLJTMHIQZ-UHFFFAOYSA-N

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards..

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA9013 in the slot below. This is an example certificate only and may not be the lot that you receive.

PHR1918

PHR2433

亚氨基芪甲酰氯, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2330

Carbamazepine Impurity C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2237

Carbamazepine Impurity B, pharmaceutical secondary standard, certified reference material

象形图

GHS07,GHS09

警示用语：

Warning

危险声明

H302 - H411

预防措施声明

P273

危险分类

Acute Tox. 4 Oral - Aquatic Chronic 2

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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部分情况下，可能未在线提供COA。如果搜索不到COA，可在线索取。

索取COA

Effect of chemical structure on complexation efficiency of aromatic drugs with cyclodextrins: The example of dibenzazepine derivatives.

Koleta Hemine et al.

Carbohydrate polymers, 250, 116957-116957 (2020-10-15)

It is widely believed that the hydrophobic effect governs the binding of guest molecules to cyclodextrins (CDs). However, it is also known that high hydrophobicity of guest molecules does not always translate to the formation of stable inclusion complexes with

Covalent binding of carbamazepine oxidative metabolites to neutrophils.

S M Furst et al.

Drug metabolism and disposition: the biological fate of chemicals, 23(5), 590-594 (1995-05-01)

Carbamazepine therapy is associated with several types of idiosyncratic drug reactions, including hematological disorders. In previous studies, we found that carbamazepine was metabolized by the myeloperoxidase/H2O2 system of activated neutrophils, and covalent binding of the drug to neutrophils was observed.

Production of specific antibodies and development of a non-isotopic immunoassay for carbamazepine by the carbonyl metallo-immunoassay (CMIA) method.

A Varenne et al.

Journal of immunological methods, 186(2), 195-204 (1995-10-26)

As part of our ongoing work to extend the range of applications of the non-isotopic carbonyl metalloimmunoassay (CMIA), previously developed in our laboratory, we describe here the first CMIA study of carbamazepine. The CMIA method uses a metal carbonyl complex

Carbamazepine metabolism to a reactive intermediate by the myeloperoxidase system of activated neutrophils.

S M Furst et al.

Biochemical pharmacology, 45(6), 1267-1275 (1993-03-24)

Carbamazepine is an anticonvulsant which is associated with a significant incidence of hypersensitivity reactions including agranulocytosis. We have postulated that many drug hypersensitivity reactions, especially agranulocytosis and lupus, are due to reactive metabolites generated by the myeloperoxidase (MPO) (EC 1.11.1.7)

Homogeneous substrate-labeled fluorescent immunoassay for carbamazepine.

T M Li et al.

Epilepsia, 23(4), 391-398 (1982-08-01)

Carbamazepine is an anticonvulsant drug useful in the management of epilepsy. Because of the narrow therapeutic range, serum carbamazepine monitoring is useful for ensuring adequate drug therapy without toxicity. We report the development of a homogeneous substrate-labeled fluorescent immunoassay for

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