PHR1225
3-氨基苯酚
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
m-Aminophenol
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线性分子式:
H2NC6H4OH
化学文摘社编号:
分子量:
109.13
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
209-711-2
Beilstein/REAXYS Number:
636059
MDL number:
InChI
1S/C6H7NO/c7-5-2-1-3-6(8)4-5/h1-4,8H,7H2
InChI key
CWLKGDAVCFYWJK-UHFFFAOYSA-N
SMILES string
Nc1cccc(O)c1
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to USP 1026004
API family
paracetamol, mesalazine, acetaminophen
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
bp
164 °C/11 mmHg (lit.)
Quality Level
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA9037 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
法规信息
危险化学品
此项目有
F Bohnenstengel et al.
Journal of chromatography. B, Biomedical sciences and applications, 692(1), 163-168 (1997-04-25)
A high-performance liquid chromatographic method for the quantification of acrolein following incubation of cyclophosphamide (CP) with human liver microsomes was developed. Based on the formation of the fluorescent derivative 7-hydroxyquinoline by condensation of acrolein with 3-aminophenol quantitation was performed without
P Nagaraja et al.
Farmaco (Societa chimica italiana : 1989), 58(12), 1295-1300 (2003-11-25)
A rapid, simple and sensitive spectrophotometric method for the determination of some sulfa drugs is described. The method is based on the formation of orange yellow colored azo product by the diazotization of sulfonamides, viz., dapsone (DAP), sulfathiazole (SFT), sulfadiazine
Mutsuko Koizumi et al.
The Journal of toxicological sciences, 27(5), 411-421 (2003-01-22)
Repeated dose toxicity of 3-aminophenol was examined on oral administration to newborn and young rats, and susceptibility was analyzed in terms of the no observed adverse effect level (NOAEL) and the unequivocally toxic level. In the 18-day newborn rat study
A new twist to an old tale: novel insights into the differential toxicities of acetaminophen and its regioisomer N-acetyl-meta-aminophenol (AMAP).
J Gerry Kenna
Archives of toxicology, 87(1), 15-18 (2012-09-25)
Toxic effects of aminophenols on aquatic life using the zebrafish embryo test and the comet assay.
L W Sun et al.
Bulletin of environmental contamination and toxicology, 73(4), 628-634 (2004-09-25)
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