PHR1244
林丹
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
γ-BHC, 1α,2α,3β,4α,5α,6β-六氯环己烷
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关于此项目
经验公式（希尔记法）:
C6H6Cl6
化学文摘社编号:
分子量:
290.83
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-401-2
Beilstein/REAXYS Number:
1907337
MDL number:
InChI key
JLYXXMFPNIAWKQ-GNIYUCBRSA-N
InChI
1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4+,5+,6+
SMILES string
Cl[C@H]1[C@H](Cl)[C@H](Cl)[C@@H](Cl)[C@H](Cl)[C@@H]1Cl
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to USP 1367504
API family
lindane
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
113-115 °C (lit.)
application(s)
cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Lindane is an organochlorine chemical, widely used as an agricultural insecticide and it also finds applications for the pharmaceutical treatment of infestations of lice and scabies.
Application
Lindane may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using gas chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA9048 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Lact. - STOT RE 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Simultaneous Determination by Gas Chromatography of Lindane and Carbaryl in Combined Formulations
Sen I, et al.
Journal of Chemistry, 8(1), 391-399 (2011)
John Vijgen et al.
Environmental science and pollution research international, 18(2), 152-162 (2010-11-26)
Hexachlorocyclohexane (HCH) isomers (α-, β- and γ- (Lindane)) were recently included as new persistent organic pollutants (POPs) in the Stockholm Convention, and therefore, the legacy of HCH and Lindane production became a contemporary topic of global relevance. This article wants
L A Videla et al.
Free radical biology & medicine, 9(2), 169-179 (1990-01-01)
The development of an oxidative stress condition in the liver by lindane intoxication is discussed as a possible hepatotoxic mechanism of the insecticide. Lindane is metabolized by liver microsomal enzymes to a variety of metabolites, which are susceptible of conjugation
Kaoruko Mizukawa et al.
Marine pollution bulletin, 70(1-2), 296-302 (2013-03-19)
We analyzed polychlorinated biphenyls (PCBs), dichlorodiphenyl dichloroethane and its metabolites, hexachlorocyclohexanes (HCHs), polycyclic aromatic hydrocarbons (PAHs), and hopanes, in plastic resin pellets collected from nine locations along the Portuguese coast. Concentrations of a sum of 13 PCBs were one order
Masahiko Okai et al.
Journal of bacteriology, 195(11), 2642-2651 (2013-04-09)
The enzymes LinB(UT) and LinB(MI) (LinB from Sphingobium japonicum UT26 and Sphingobium sp. MI1205, respectively) catalyze the hydrolytic dechlorination of β-hexachlorocyclohexane (β-HCH) and yield different products, 2,3,4,5,6-pentachlorocyclohexanol (PCHL) and 2,3,5,6-tetrachlorocyclohexane-1,4-diol (TCDL), respectively, despite their 98% identity in amino acid sequence.
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