PHR1270
富马酸
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
富马酸
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关于此项目
线性分子式:
HOOCCH=CHCOOH
化学文摘社编号:
分子量:
116.07
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
203-743-0
Beilstein/REAXYS Number:
605763
MDL number:
InChI key
VZCYOOQTPOCHFL-OWOJBTEDSA-N
InChI
1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+
SMILES string
OC(=O)\C=C\C(O)=O
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. F0600000, traceable to USP 1286708
vapor pressure
1.7 mmHg ( 165 °C)
API family
fumaric acid
CofA
current certificate can be downloaded
autoignition temp.
1364 °F
expl. lim.
40 %
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
298-300 °C (subl.) (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
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General description
用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
Application
富马酸可作为药物参考标准品，通过分光光度法对药物制剂中的分析物进行测定。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Other Notes
在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。
要查看该材料的分析证书示例，请在下面的栏位中输入 LRAC1693。这只是一个示例证书，可能不是您收到的批次。
该认证参考物质（CRM）根据ISO 17034和ISO/IEC 17025进行生产和认证。所有关于该 CRM 的信息都可以在分析证书上找到。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
wgk
WGK 1
存储类别
11 - Combustible Solids
flash_point_f
523.4 °F
flash_point_c
273 °C
Spectrophotometric estimation of ketotifen fumarate in pharmaceutical formulations
Sastry CSP and Naidu PY
Microchimica Acta, 127(3-4), 219-223 (1997)
Spectrophotometric determination of ascorbic acid in pharmaceuticals by background correction and flow injection
Verma KK, et al.
Analyst, 116(6), 641-645 (1991)
Management of psoriasis vulgaris and multiple sclerosis with fumaric acid.
Spyridon Gkalpakiotis et al.
Journal of the American Academy of Dermatology, 70(3), e60-e61 (2014-02-18)
R Gold et al.
Clinical immunology (Orlando, Fla.), 142(1), 44-48 (2011-03-19)
Fumaric acid was originally therapeutically used in psoriasis. Several lines of evidence have demonstrated immunomodulatory but also neuroprotective effects for FAE. Clinical studies in psoriasis showed a reduction of peripheral CD4+ and CD8+ T-lymphocytes due to the ability of FAE
B Sebók et al.
Orvosi hetilap, 141(3), 129-132 (2000-02-29)
The treatment of psoriasis vulgaris with fumaric acid esters has been controversial for more than 30 years. Recently the fumaric acid derivatives are marketed antipsoriatics in many European countries. In this paper the clinical efficacy, the side effects as well
商品
A new RP-HPLC method is proposed for the determination of organic acids in 100% aqueous mobile phase using an Ascentis® Express AQ-C18 column
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