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Merck
CN

PHR1289

Supelco

马来酸依那普利

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

依那普利 马来酸盐, ( S )-N-[1-（乙氧基羰基）-3-苯基丙基]-Ala-Pro 马来酸盐

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关于此项目

经验公式（希尔记法）:
C20H28N2O5 · C4H4O4
CAS Number:
76095-16-4
分子量:
492.52
EC 号:
278-375-7
UNSPSC代码:
41116107
NACRES:
NA.24

主要文件

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等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

USP 1235300
traceable to Ph. Eur. E0109000

API类

enalapril

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-30°C

SMILES字符串

C[C@@H](C(N1[C@H](C(O)=O)CCC1)=O)N[C@H](CC(OCC)=O)CCC2=CC=CC=C2.O=C(OO)/C=C\C(O)=O

InChI

1S/C21H30N2O5.C4H4O5/c1-3-28-19(24)14-17(12-11-16-8-5-4-6-9-16)22-15(2)20(25)23-13-7-10-18(23)21(26)27;5-3(6)1-2-4(7)9-8/h4-6,8-9,15,17-18,22H,3,7,10-14H2,1-2H3,(H,26,27);1-2,8H,(H,5,6)/b;2-1-/t15-,17-,18-;/m0./s1

InChI key

UQKQUZOIQFOJOI-KJHLASMFSA-N

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相关类别

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Enalapril Maleate is a drug, which is widely used as an antihypertensive and a vasodilator in congestive heart failure. It is a derivative of 2 amino acids such as L-alanine and L-proline.

应用

Enalapril Maleate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using derivative UV spectrophotometry and chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

一种长效血管紧张素转换酶抑制剂。

分析说明

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3898 in the slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H361fd

危险分类

Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 2

分析证书(COA)

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Determination of hydrochlorothiazide and enalapril maleate in tablet formulations by reversed-phase HPLC
Al-Momani GI
Turkish Journal of Chemistry, 25(1), 49-54 (2001)
Simultaneous determination of enalapril maleate and hydrochlorothiazide in tablets by derivative UV spectrophotometry and high-performance liquid chromatography
Carlucci G, et al.
International Journal of Pharmaceutics, 93(1-3), 245-248 (1993)
Changhyun Lee et al.
Life sciences, 95(1), 29-39 (2013-11-19)
Enalapril, an angiotensin-converting enzyme (ACE) inhibitor, has pleiotropic effects such as anti-inflammatory effects. This study investigated the effect of enalapril on the nuclear factor-kappa B (NF-κB) pathway and on experimental colitis. The human intestinal epithelial cell (IEC) line COLO 205
Norma B Ojeda et al.
American journal of physiology. Renal physiology, 304(7), F900-F907 (2013-01-25)
This study tested the hypothesis that Rho kinase contributes to the enhanced pressor response to acute angiotensin II in intact male growth-restricted and gonadectomized female growth-restricted rats. Mean arterial pressure (MAP) and renal function were determined in conscious animals pretreated
Justin Brewer et al.
Hypertension (Dallas, Tex. : 1979), 62(5), 886-892 (2013-09-18)
Hypertension during preeclampsia is associated with increased maternal vascular sensitivity to angiotensin II (ANGII). This study was designed to determine mechanisms whereby agonistic autoantibodies to the ANGII type I receptor (AT1-AA) enhance blood pressure (mean arterial pressure [MAP]) and renal
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最新推出的满足海关审查要求的标准物质

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