PHR1296
联苯苄唑
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
1-（对,α-二苯基苄基）咪唑
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关于此项目
经验公式（希尔记法）:
C22H18N2
化学文摘社编号:
分子量:
310.39
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
262-336-6
MDL number:
产品名称
联苯苄唑, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
OCAPBUJLXMYKEJ-UHFFFAOYSA-N
InChI
1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H
SMILES string
c1ccc(cc1)C(c2ccc(cc2)-c3ccccc3)n4ccnc4
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. B1110000
API family
bifonazole
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
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Biochem/physiol Actions
联苯苄唑是一种咪唑类抗真菌剂，对许多真菌、霉菌、酵母和一些革兰氏阳性菌具有广谱活性。联苯苄唑抑制麦角固醇生物合成蛋白 28 和细胞色素 P450 2B4。
Application
联苯苄唑可用作药物参考标准品，用于通过分光光度技术测定药物制剂中的分析物。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
General description
用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。
联苯苄唑是一种取代咪唑类似物，具有治疗侵袭性粘膜感染的治疗潜力。它通过抑制侵袭皮肤和指甲的皮肤癣菌、酵母菌和真菌的增殖而表现出抗真菌活性。其作用方式包括阻断真菌麦角固醇生物合成途径和抑制萜类生物合成。
联苯苄唑是一种取代咪唑类似物，具有治疗侵袭性粘膜感染的治疗潜力。它通过抑制侵袭皮肤和指甲的皮肤癣菌、酵母菌和真菌的增殖而表现出抗真菌活性。其作用方式包括阻断真菌麦角固醇生物合成途径和抑制萜类生物合成。
Other Notes
想要查看本品的检验报告示例，请在下框中输入LRAC3256。这只是一个示例证书，可能与您收到的批次不符。
该认证标准物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在检验报告上找到。
Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Validated spectrophotometric methods for the determination of bifonazole in pharmaceuticals by charge transfer complexation
Ismail SBN, et al.
Journal of the Association of Arab Universities for Basic and Applied Sciences, 19(1), 8-14 (2016)
Determination of bifonazole in creams containing methyl-and propyl p-hydroxybenzoate by derivative spectrophotometric method
Popovic G, et al.
Journal of Pharmaceutical and Biomedical Analysis, 33(1), 131-136 (2003)
Betty Wächtler et al.
Antimicrobial agents and chemotherapy, 55(9), 4436-4439 (2011-07-13)
Clotrimazole and bifonazole are highly effective antifungal agents against mucosal Candida albicans infections. Here we examined the effects of low levels of clotrimazole and bifonazole on the ability of C. albicans to adhere, invade, and damage vaginal epithelial cells. Although
Shinichi Watanabe et al.
Mycoses, 49(3), 236-241 (2006-05-10)
The aim of the study was to compare the efficacy and safety of luliconazole 1% cream and bifonazole 1% cream as applied in the treatment of tinea pedis (interdigital-type and plantar-type). A multi-clinic, randomised single-blind, parallel group study with 34
Salomé El Hage et al.
Archiv der Pharmazie, 344(6), 402-410 (2011-03-25)
Two series of chlorinated benzhydryl imidazole and triazole derivatives were synthesized and tested in vitro against representative strains of potent pathogenic bacteria (Staphylococcus aureus CIP 4.83, Escherichia hirae CIP 5855, Pseudomonas aeruginosa CIP 82118, Escherichia coli CIP 53126) and fungi
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