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Merck
CN

PHR1376

Supelco

氯雷他定

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

氯雷他定, 4-（8-氯-5,6-二氢-11H-苯并[5,6]环庚[1,2-b]吡啶-11-亚基-1-哌啶羧酸乙酯

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关于此项目

经验公式（希尔记法）:
C22H23N2O2Cl
化学文摘社编号:
79794-75-5
分子量:
382.88
MDL编号:
MFCD00672869
UNSPSC代码:
41116107
PubChem化学物质编号:
329823353
NACRES:
NA.24

主要文件

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等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

USP 1370270
traceable to Ph. Eur. Y0000688

API类

loratadine

CofA

current certificate can be downloaded

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-30°C

SMILES字符串

CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24

InChI

1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChI key

JCCNYMKQOSZNPW-UHFFFAOYSA-N

基因信息

human ... HRH1(3269)

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相关类别

一般描述

氯雷他定是没有镇静作用的H1抗组胺类药物，广泛用于过敏治疗。

应用

氯雷他定(Loratadine)可用作药物参考标准品，用于通过分光光度技术测定药物制剂中的分析物。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

生化/生理作用

非镇静组胺H1-受体拮抗剂。

分析说明

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

其他说明

想要查看本品的检验报告(CoA)示例，请在下框中输入LRAC3785。这只是一个示例证书，可能与您收到的批次不符。
该认证标准物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在检验报告上找到。

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Determination of loratadine in pharmaceuticals by a spectrophotometric method
Pavalanche G, et al.
Ovidius University Annals of Chemistry, 26(1), 27-31 (2015)
J A Hey et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 29 Suppl 3, 197-199 (1999-08-12)
The extremely low reporting rate of cardiovascular adverse events for loratadine, the possible preferential use of loratadine in patients with pre-existing cardiovascular disorders, and the impressive lack of cardiovascular effects at extremely high concentrations in clinical and preclinical studies demonstrate
H A Barenholtz et al.
DICP : the annals of pharmacotherapy, 23(6), 445-450 (1989-06-01)
Loratadine is an addition to the class of nonsedating antihistamines which includes terfenadine, astemizole, and acrivastine. Loratadine is chemically related to the tricyclic antidepressants. Animal data have shown that insignificant amounts of loratadine enter the brain, and it has a
S P Clissold et al.
Drugs, 37(1), 42-57 (1989-01-01)
Loratadine is a long acting antihistamine which has a high selectivity for peripheral histamine H1-receptors and lacks the central nervous system depressant effects often associated with some of the older antihistamines. Results from controlled clinical trials have shown that loratadine
Eleanor B Schwarz et al.
Drug safety, 31(9), 775-788 (2008-08-19)
Loratadine, a second-generation antihistamine, is commonly used to treat seasonal allergies. Some studies have suggested that use of loratadine by pregnant women increases the risk of hypospadias in male offspring. This meta-analysis was designed to assess the strength of the
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商品

LC-MS Analysis of Serum for a Wide Analyte Range Using a Novel HLB SPE Phase

Analysis of 20 pharmaceutical compounds in calf serum using Supel™ Swift HLB SPE cartridge for cleanup and LC-MS determination and another commercially available HLB cartridge for comparison.

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