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文件

PHR1376

Supelco

氯雷他定

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
氯雷他定, 4-（8-氯-5,6-二氢-11H-苯并[5,6]环庚[1,2-b]吡啶-11-亚基-1-哌啶羧酸乙酯
经验公式（希尔记法）:
C22H23N2O2Cl
CAS号:
79794-75-5
分子量:
382.88
MDL编号:
MFCD00672869
PubChem化学物质编号:
329823353
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 874
traceable to Ph. Eur. Y0000688
traceable to USP 1370270

API family

loratadine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES string

CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24

InChI

1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChI key

JCCNYMKQOSZNPW-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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相关类别

一般描述

氯雷他定是没有镇静作用的H1抗组胺类药物，广泛用于过敏治疗。

应用

氯雷他定(Loratadine)可用作药物参考标准品，用于通过分光光度技术测定药物制剂中的分析物。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

生化/生理作用

非镇静组胺H1-受体拮抗剂。

分析说明

这些二级标准品可追溯至USP、EP（PhEur）和BP一级标准品。

其他说明

该认证标准物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在检验报告上找到。

附注

想要查看本品的检验报告(CoA)示例，请在下框中输入LRAC3785。这只是一个示例证书，可能与您收到的批次不符。

相关产品

产品编号
说明
价格

1370280

地氯雷他定, United States Pharmacopeia (USP) Reference Standard

1370270

氯雷他定, United States Pharmacopeia (USP) Reference Standard

1370291

Loratadine Related Compound B, United States Pharmacopeia (USP) Reference Standard

Y0000603

氯雷他定, European Pharmacopoeia (EP) Reference Standard

Y0000688

氯雷他定, European Pharmacopoeia (EP) Reference Standard

Y0000604

氯雷他定杂质F, European Pharmacopoeia (EP) Reference Standard

Y0000605

氯雷他定杂质H, European Pharmacopoeia (EP) Reference Standard

1370269

Loratadine Related Compound C, United States Pharmacopeia (USP) Reference Standard

BP874

氯雷他定, British Pharmacopoeia (BP) Reference Standard

BP875

氯雷他定, British Pharmacopoeia (BP) Reference Standard

PHR2308

Loratadine Related Compound B

PHR2309

Loratadine Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Standard

PHR2313

N-乙氧羰基-4-哌啶酮, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2310

Loratadine Impurity A, certified reference material, pharmaceutical secondary standard

PHR2311

Loratadine Impurity E, Pharmaceutical Secondary Standard; Certified Reference Material

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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索取COA

Determination of loratadine in pharmaceuticals by a spectrophotometric method
Pavalanche G, et al.
Ovidius University Annals of Chemistry, 26(1), 27-31 (2015)
G G Kay et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 29 Suppl 3, 147-150 (1999-08-12)
Although equally potent at blocking the H1 receptor, first- and second-generation antihistamines can be distinguished with respect to their different effects on the central nervous system (CNS). First-generation antihistamines readily cross the blood-brain barrier leading to significant drowsiness, altered mood
S P Clissold et al.
Drugs, 37(1), 42-57 (1989-01-01)
Loratadine is a long acting antihistamine which has a high selectivity for peripheral histamine H1-receptors and lacks the central nervous system depressant effects often associated with some of the older antihistamines. Results from controlled clinical trials have shown that loratadine
Safety and efficacy of loratadine in urticaria.
E W Monroe
International journal of dermatology, 35(12), 837-841 (1996-12-01)
J A Hey et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 29 Suppl 3, 197-199 (1999-08-12)
The extremely low reporting rate of cardiovascular adverse events for loratadine, the possible preferential use of loratadine in patients with pre-existing cardiovascular disorders, and the impressive lack of cardiovascular effects at extremely high concentrations in clinical and preclinical studies demonstrate
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