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Merck
CN

PHR1403

酚妥拉明

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

酚妥拉明 甲磺酸盐, 2-(N-[m-羟基苯基]-p-甲苯氨基甲基)咪唑啉

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线性分子式:
C17H19N3O · CH3SO3H
化学文摘社编号:
65-28-1
分子量:
377.46
NACRES:
NA.24
PubChem Substance ID:
329823376
UNSPSC Code:
41116107
EC Number:
200-604-6
MDL number:
MFCD00134201

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产品名称

酚妥拉明, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

OGIYDFVHFQEFKQ-UHFFFAOYSA-N

InChI

1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)

SMILES string

CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001127
traceable to USP 1530004

API family

phentolamine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

180-182 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

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相关类别

Biochem/physiol Actions

α-肾上腺素受体拮抗剂；外周血管舒张剂。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Phentolamine Mesylate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chemiluminescence technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Phentolamine Mesylate belongs to the class of alpha adrenergic antagonist drugs. It is used in the treatment of pheochromocytoma-related hypertension, erectile dysfunction and in the diagnosis of pheochromocytoma and norepinephrine-related dermal necrosis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3261 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Phentolamine mesylate relaxes penile corpus cavernosum tissue by adrenergic and non-adrenergic mechanisms
Traish A, et al.
International Journal of Impotence Research, 10(4), 215-215 (1998)
Long-term safety and efficacy of oral phentolamine mesylate (Vasomax?) in men with mild to moderate erectile dysfunction
Padma-Nathan H, et al.
International Journal of Impotence Research, 14(4), 266-266 (2002)
Sensitive chemiluminescence determination of phentolamine mesylate and phenoxybenzamine hydrochloride based on K3Fe (CN) 6-H2O2-fluorescein
Xing L, et al.
Journal of Luminescence, 137(4), 162-167 (2013)
Pharmacokinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate
Moore PA, et al.
Anesthesia Progress, 55(2), 40-48 (2008)
Xianming Su et al.
Journal of cardiovascular pharmacology, 65(1), 62-71 (2014-09-30)
Previous studies have found that Danhong injection (DHI), an extensively used herbal extract preparation in China, might be a powerful vasodilator. The aims of this study were to determine the vascular activity of DHI and its effects on arteries of

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