产品名称
膦甲酸钠, Pharmaceutical Secondary Standard; Certified Reference Material
SMILES string
[Na+].[Na+].[Na+].[P](=O)([O-])([O-])C(=O)[O-].O.O.O.O.O.O
InChI
1S/CH3O5P.3Na.6H2O/c2-1(3)7(4,5)6;;;;;;;;;/h(H,2,3)(H2,4,5,6);;;;6*1H2/q;3*+1;;;;;;/p-3
InChI key
ILRVASBWNRYBFD-UHFFFAOYSA-K
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. F0389000
traceable to USP 1283302
API family
foscarnet
CofA
current certificate can be downloaded
packaging
pkg of 1 g
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
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Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Application
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Foscarnet Sodium is a selective inhibitor of herpes simplex virus (HSV). It is an antiviral agent used in the treatment of cytomegalovirun retinitis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA3051 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Warning
hcodes
Hazard Classifications
Muta. 2 - STOT RE 2
target_organs
Kidney,Bone
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Efficacy and safety of foscarnet for recurrent orolabial herpes: a multicentre randomized double-blind study.
Lawee D, et al.
CMAJ : Canadian Medical Association Journal = Journal de l'Association Medicale Canadienne, 138(4), 329-329 (1988)
Jocelyne Piret et al.
Journal of virology, 89(8), 4636-4644 (2015-02-13)
DNA polymerases of the Herpesviridae and bacteriophage RB69 belong to the α-like DNA polymerase family. In spite of similarities in structure and function, the RB69 enzyme is relatively resistant to foscarnet, requiring the mutation V478W in helix N to promote
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