PHR1441
硫酸壮观霉素
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
硫酸壮观霉素 四水合物
SMILES string
[S](=O)(=O)(O)O.N([C@@H]1[C@H]2O[C@@]3([C@H](O[C@@H]2[C@H]([C@@H]([C@@H]1O)NC)O)O[C@@H](CC3=O)C)O)C.O.O.O.O
InChI
1S/C14H24N2O7.H2O4S.4H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;1-5(2,3)4;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;(H2,1,2,3,4);4*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;/m1...../s1
InChI key
OBZDRKHRQYPQDZ-SACNDDTHSA-N
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. Y0000655, traceable to USP 1618003
API family
spectinomycin
CofA
current certificate can be downloaded
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
General description
Spectinomycin is an aminoglycoside-like antibiotic produced by Streptomyces spectabilis. It is widely used as a veterinary medication to treat gastrointestinal and respiratory infections caused by a variety of spectinomycin-sensitive micro-organisms.
Application
Spectinomycin Sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in spectinomycin formulations using high-performance liquid chromatography technique.
Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. It is recommended for use in cell culture applications at 7.5-20 mg/L.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Preparation Note
Stock solutions should be prepared at 10 mg/mL in water and filter sterilized.
Other Notes
To see an example of a Certificate of Analysis for this material enter LRAB3670 in the slot below. This is an example certificate only and may not be the lot that you receive.
Legal Information
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available. This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDE 34:2009 (AClass Cert AR-1470).
Disclaimer
Solutions can be stored at 2-8°C for several weeks or at -20°C for more extended periods.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
A validated stability-indicating HPLC method for routine analysis of an injectable lincomycin and spectinomycin formulation
Abualhasan NM, et al.
Scientia Pharmaceutica, 80(4), 977-986 (2012)
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