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文件

PHR1446

雷米普利

Name: 雷米普利
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:

Tritace, [2S,3aS,6aS]-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid

经验公式（希尔记法）:

C₂₃H₃₂N₂O₅

CAS号:

87333-19-5

分子量:

416.51

MDL编号:

MFCD00865775

PubChem化学物质编号:

329822606

NACRES:

NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 751
traceable to Ph. Eur. R0145000
traceable to USP 1598303

API family

ramipril

CofA

current certificate can be downloaded

包装

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

O=C(N1[C@](CCC2)([H])[C@]2([H])C[C@H]1C(O)=O)[C@H](C)N[C@H](C(OCC)=O)CCC3=CC=CC=C3

InChI

1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1

InChI key

HDACQVRGBOVJII-JBDAPHQKSA-N

Gene Information

human ... ACE(1636)

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一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Ramipril is an angiotensin-converting-enzyme (ACE) inhibitor, which acts on the renin angiotensin aldosterone system. It is widely used in reducing hypertension by the suppression of the effects of angiotensin II at its receptor, thereby blocking the renin-angiotensin system.

应用

Ramipril may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and high-performance liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

Angiotensin converting enzyme (ACE) inhibitor.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3757 in the slot below. This is an example certificate only and may not be the lot that you receive.

1598303

雷米普利, United States Pharmacopeia (USP) Reference Standard

1598314

1598347

1598323

1598338

BP751

雷米普利, British Pharmacopoeia (BP) Reference Standard

BP754

Ramipril impurity K, British Pharmacopoeia (BP) Reference Standard

象形图

GHS08

警示用语：

Danger

危险声明

H360FD

预防措施声明

P201 - P202 - P280 - P308 + P313 - P405 - P501

危险分类

Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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Development and validation of simultaneous HPLC method for estimation of telmisartan and ramipril in pharmaceutical formulations

Jawla S, et al.

International Journal of PharmTech Research, 2(2), 1625-1633 (2010)

Simultaneous determination of ramipril, hydrochlorothizide and telmisartan by spectrophotometry

Bankey S, et al.

International Journal of ChemTech Research, 1(2), 183-188 (2009)

A Spectrophotometric method for the determination of ramipril in solid dosage forms

Afleroho EO, et al.

Tropical Journal of Pharmaceutical Research, 11(2), 275-279 (2012)

A validated HPLC method for analysis of atorvastatin calcium, ramipril and aspirin as the bulk drug and in combined capsule dosage Forms

Patole MS, et al.

International Journal of Pharmaceutical Sciences Review and Research, 4(3), 40-45 (2010)

Statistical optimization and in-vitro evaluation of hollow microcapsules of an anti-hypertensive agent.

Tushar A Premchandani et al.

Acta poloniae pharmaceutica, 71(1), 95-106 (2014-05-02)

The present work attempts to formulate and evaluate hollow microcapsules of an antihypertensive drug--ramipril, which will remain in vicinity of absorption site. The emulsion diffusion solvent evaporation method was employed for preparation of microspheres using Eudragit E100. Glycerol monostearate and

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