PHR1476
邻苯二甲酸二乙酯
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
邻苯二甲酸二乙酯, DEP
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线性分子式:
C6H4-1,2-(CO2C2H5)2
化学文摘社编号:
分子量:
222.24
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
201-550-6
Beilstein/REAXYS Number:
1912500
MDL number:
产品名称
邻苯二甲酸二乙酯, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
FLKPEMZONWLCSK-UHFFFAOYSA-N
InChI
1S/C12H14O4/c1-3-15-11(13)9-7-5-6-8-10(9)12(14)16-4-2/h5-8H,3-4H2,1-2H3
SMILES string
CCOC(=O)c1ccccc1C(=O)OCC
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. D1410000
traceable to USP 1193505
vapor density
7.66 (vs air)
vapor pressure
1 mmHg ( 100 °C)
API family
diethyl phthalate
CofA
current certificate can be downloaded
autoignition temp.
854 °F
expl. lim.
0.75 %, 187 °F
packaging
pkg of 1 g
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
refractive index
n20/D 1.502 (lit.)
bp
298-299 °C (lit.)
mp
−3 °C (lit.)
density
1.12 g/mL at 25 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Application
Diethyl Phthalate may be used as a pharmaceutical reference standard for the determination of the analyte in cosmetic products, pharmaceutical formulations and dietary supplements by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Diethyl Phthalate is a phthalic acid ester, commonly synthesized by the condensation of the carboxy groups of phthalic acid with methanol.. It is used as a solvent for fragrance in cosmetic formulations and personal care products.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA3024 in the slot below. This is an example certificate only and may not be the lot that you receive.
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
338.0 °F - closed cup
flash_point_c
170 °C - closed cup
Phthalic Acid and Derivatives
Ullmann's Encyclopedia of Industrial Chemistry (2007)
Identification of phthalates in medications and dietary supplement formulations in the United States and Canada
Kelley K, et al.
Environmental Health Perspectives, 120(3), 379-384 (2011)
Gas chromatography in routine pharmaceutical analysis
Baines CB and Proctor KA
The Journal of Pharmacy and Pharmacology, 11(S1), 230T-234T (1959)
Analysis of consumer cosmetic products for phthalate esters.
Hubinger JC and Havery DC
Journal of Cosmetic Science, 57(2), 127-137 (2006)
Simultaneous determination of seven phthalates and four parabens in cosmetic products using HPLC-DAD and GC-MS methods
Shen Y-H, et al.
Journal of Separation Science, 30(1), 48-54 (2007)
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