PHR1492
苯妥英钠
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
5,5-二苯基海因 钠盐, 5,5-联苯基乙内酰脲, 苯妥英
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线性分子式:
C15H11N2O2Na
化学文摘社编号:
分子量:
274.25
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
211-148-2
MDL number:
产品名称
苯妥英钠, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
FJPYVLNWWICYDW-UHFFFAOYSA-M
InChI
1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
SMILES string
[Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. P1300000
traceable to USP 1535507
API family
phenytoin
CofA
current certificate can be downloaded
packaging
pkg of 1 g
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
Gene Information
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Biochem/physiol Actions
减少癫痫大发作的发生率；可能通过 Na+、K+ 和 Ca2+ 通道的影响而稳定可兴奋膜。
Reduces incidence of grand mal seizures; appears to stabilize excitable membranes.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Application
Phenytoin sodium may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA3040 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Differential derivative spectrophotometric determination of phenobarbitone and phenytoin sodium in combined tablet preparations
Prasad CVN, et al.
Talanta, 44(5), 917-922 (1997)
Method Development and Validation of Phenytoin Sodium in bulk and its Pharmaceutical dosage form by RP-HPLC method
Varaprasad A, et al.
International Journal of Biological & Pharmaceutical Research, 3(5), 126-129 (2012)
Zin-Juan Klaft et al.
Neuropharmacology, 176, 108213-108213 (2020-07-03)
Status epilepticus (SE) is a neurological emergency characterized by continuous seizure activity lasting longer than 5 min, often with no recovery between seizures (Trinka et al., 2015). SE is refractory to benzodiazepine and second-line treatments in about 30% cases. Novel treatment
Maria B Rabaglino et al.
BMC genomics, 15, 1001-1001 (2014-11-21)
Major changes in gene expression occur in the fetal brain to modulate the function of this organ postnatally. Thus, factors can alter the genomics of the fetal brain, predisposing to neurological disorders later in life. We hypothesized that the physiological
Shareef Ahmed et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 30(10), 823-830 (2014-08-29)
To determine whether penetrating scleral or corneal injury can enhance intraocular penetration of systemic moxifloxacin, vancomycin, and ceftazidime. Thirty rabbits were divided into 3 groups for each antibiotic and then further subdivided to receive either scleral or corneal injury to
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