PHR1492
苯妥英钠
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
5,5-二苯基海因 钠盐, 5,5-联苯基乙内酰脲, 苯妥英
等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to Ph. Eur. P1300000
traceable to USP 1535507
API类
phenytoin
CofA
current certificate can be downloaded
包装
pkg of 1 g
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-30°C
SMILES字符串
[Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
InChI
1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
InChI key
FJPYVLNWWICYDW-UHFFFAOYSA-M
基因信息
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一般描述
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
应用
Phenytoin sodium may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
生化/生理作用
减少癫痫大发作的发生率；可能通过 Na+、K+ 和 Ca2+ 通道的影响而稳定可兴奋膜。
Reduces incidence of grand mal seizures; appears to stabilize excitable membranes.
分析说明
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
其他说明
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA3040 in the slot below. This is an example certificate only and may not be the lot that you receive.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Differential derivative spectrophotometric determination of phenobarbitone and phenytoin sodium in combined tablet preparations
Prasad CVN, et al.
Talanta, 44(5), 917-922 (1997)
Zin-Juan Klaft et al.
Neuropharmacology, 176, 108213-108213 (2020-07-03)
Status epilepticus (SE) is a neurological emergency characterized by continuous seizure activity lasting longer than 5 min, often with no recovery between seizures (Trinka et al., 2015). SE is refractory to benzodiazepine and second-line treatments in about 30% cases. Novel treatment
Method Development and Validation of Phenytoin Sodium in bulk and its Pharmaceutical dosage form by RP-HPLC method
Varaprasad A, et al.
International Journal of Biological & Pharmaceutical Research, 3(5), 126-129 (2012)
Misty Good et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(11), G1021-G1032 (2014-04-20)
Necrotizing enterocolitis (NEC) is the leading cause of death from gastrointestinal disease in premature infants and develops partly from an exaggerated intestinal epithelial immune response to indigenous microbes. There has been interest in administering probiotic bacteria to reduce NEC severity
Shareef Ahmed et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 30(10), 823-830 (2014-08-29)
To determine whether penetrating scleral or corneal injury can enhance intraocular penetration of systemic moxifloxacin, vancomycin, and ceftazidime. Thirty rabbits were divided into 3 groups for each antibiotic and then further subdivided to receive either scleral or corneal injury to
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