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Merck
CN

PHR1583

醋酸甲地孕酮

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

醋酸甲地孕酮, 17α-乙酰氧基-6-甲基孕甾-4,6-二烯-3,20-二酮, 17α-羟基-6-甲基-6-去氢孕酮 17-乙酸酯, 17α-羟基-6-甲基孕甾-4,6-二烯-3,20-二酮 17-乙酸酯, 甲地孕酮 17-乙酸酯

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经验公式（希尔记法）:
C24H32O4
化学文摘社编号:
595-33-5
分子量:
384.51
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823491
EC Number:
209-864-5
Beilstein/REAXYS Number:
1917291
MDL number:
MFCD00056470

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InChI key

RQZAXGRLVPAYTJ-GQFGMJRRSA-N

InChI

1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1

SMILES string

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@]3(OC(C)=O)C(C)=O)[C@]1([H])C=C(C)C4=CC(=O)CC[C@]24C

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001514, traceable to USP 1379106

API family

megesterol

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... PGR(5241)

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Megestrol Acetate is a progestogen drug indicated for the palliative treatment of endometrial carcinoma and breast cancer. The administration of the drug is usually done orally as a solid dosage form.

Application

Megestrol Acetate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, oral contraceptives and suspensions by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Other Notes

To see an example of a Certificate of Analysis for this material enter LRAA4562 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360FD

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Jianghuan Hua et al.
Ecotoxicology and environmental safety, 163, 289-297 (2018-07-30)
Synthetic progestins are widely used pharmaceutical agents that have become common contaminants in the aquatic environment. The potential adverse effects of long-term exposure on aquatic wildlife, however, are not fully understood. The aim of this study was to investigate the
Improved bioavailability of a micronized megestrol acetate tablet formulation in humans
Farinha A, et al.
Drug Development and Industrial Pharmacy, 26(5), 567-570 (2000)
Food effect on the bioavailability of two distinct formulations of megestrol acetate oral suspension
Deschamps B, et al.
International journal of nanomedicine, 4, 185-185 (2009)
Thin-layer chromatographic identification of estrogens and progestogens in oral contraceptives
Simard MB and Lodge BA
Journal of Chromatography A, 51, 517-524 (1970)
Medroxyprogesterone Acetate
USP42-NF37
United States Pharmacopeia/National Formulary, 42(6), 2715-2715 (2018)
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