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Merck
CN

PHR1592

Supelco

替诺福韦

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid monohydrate, 1-(6-Aminopurin-9-yl) propan-2-yl-oxymethylphosphonic acid, TEN

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关于此项目

经验公式（希尔记法）:
C9H14N5O4P · H2O
化学文摘社编号:
206184-49-8
分子量:
305.23
UNSPSC代码:
41116107
NACRES:
NA.24

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等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to USP 1643601

API类

tenofovir

CofA

current certificate can be downloaded

包装

pkg of 1 g

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

[P](=O)(O)(O)CO[C@@H](C[n]1c2ncnc(c2nc1)N)C.O

InChI

1S/C9H14N5O4P.H2O/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14;/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17);1H2/t6-;/m1./s1

InChI key

PINIEAOMWQJGBW-FYZOBXCZSA-N

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相关类别

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Tenofovir is a nucleotide analog reverse transcriptase inhibitor, and is widely used as an antiretroviral agent, for the treatment of HIV infection.

应用

Tenofovir may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance thin layer chromatography (HPTLC) technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3475 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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Validated HPTLC method for the determination of tenofovir as bulk drug and in pharmaceutical dosage form
Pradeep K, et al.
Research Journal of Chemical Sciences, 1(7), 33-37 (2011)
HPTLC method for the simultaneous estimation of emtricitabine and tenofovir in tablet dosage form
Joshi M, et al.
Indian Journal of Pharmaceutical Sciences, 71(1), 95-95 (2009)

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