PHR1680
地氯雷他定
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
地氯雷他定, 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine, Clarinex®
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关于此项目
经验公式（希尔记法）:
C19H19ClN2
化学文摘社编号:
分子量:
310.82
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
SMILES string
Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1
InChI key
JAUOIFJMECXRGI-UHFFFAOYSA-N
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. Y0001584, traceable to USP 1173042
API family
desloratidine
CofA
current certificate can be downloaded
packaging
pkg of 1 g
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
Gene Information
human ... HRH1(3269)
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Desloratadine is one of the orally active, highly selective peripheral H1 receptor antagonists that does not exert any significant effect on the central and autonomic nervous systems. The potency of desloratadine is more than that of loratadine and it exhibits substantial overall pharmacological profile.
Desloratadine is one of the orally active, highly selective peripheral H1 receptor antagonists that does not exert any significant effect on the central and autonomic nervous systems. The potency of desloratadine is more than that of loratadine and it exhibits substantial overall pharmacological profile.
Application
Desloratadine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions
A non-sedating H1-receptor antagonist, free from antimuscarinic/anticholinergic effects. It has novel antiallergic and anti-inflammatory effects.
Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC2775 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
Legal Information
Clarinex is a registered trademark of Schering Corp.
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
390.2 °F - Pensky-Martens closed cup
flash_point_c
199 °C - Pensky-Martens closed cup
A validated stability-indicating UPLC method for desloratadine and its impurities in pharmaceutical dosage forms.
Rao DD, et al.
Journal of Pharmaceutical and Biomedical Analysis, 51(3), 736-742 (2010)
Spectrophotometric, spectrofluorometric and HPLC determination of desloratadine in dosage forms and human plasma.
El-Enany N, et al.
Chemical & Pharmaceutical Bulletin, 55(12), 1662-1670 (2007)
High-performance liquid chromatographic method for the bioequivalence evaluation of desloratadine fumarate tablets in dogs.
Liu L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 34(5), 1013-1019 (2004)
Determination of desloratadine in drug substance and pharmaceutical preparations by liquid chromatography.
Qi M, et al.
Journal of Pharmaceutical and Biomedical Analysis, 38(2), 355-359 (2005)
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