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Merck
CN

PHR1714

Supelco

炔诺酮（去甲脱氢羟孕酮）

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

17-羟基-19-去甲-17α-孕甾-4-烯-20-炔基-3-酮, 17α-乙炔基-19-去甲睾酮, 19-去甲-17α-乙炔基-4-雄甾烯-17β-醇-3-酮, 去甲基脱氢羟孕酮, 炔诺酮

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关于此项目

经验公式（希尔记法）:
C20H26O2
化学文摘社编号:
68-22-4
分子量:
298.42
EC 号:
200-681-6
MDL编号:
MFCD00067596
UNSPSC代码:
41116107
PubChem化学物质编号:
329823570
NACRES:
NA.24

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等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. N1200000
traceable to USP 1469005

API类

norethindrone

CofA

current certificate can be downloaded

包装

pkg of 1 g

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-30°C

SMILES字符串

O[C@@]1([C@@]2([C@H]([C@H]3[C@@H]([C@H]4CCC(=O)C=C4CC3)CC2)CC1)C)C#C

InChI

1S/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,12,15-18,22H,4-11H2,2H3/t15-,16+,17+,18-,19-,20-/m0/s1

InChI key

VIKNJXKGJWUCNN-XGXHKTLJSA-N

基因信息

human ... PGR(5241)

相关类别

一般描述

Norethindrone (Norethisterone) is a progestin medication, widely used to treat gynecological irregularities such as premenstrual syndrome, painful periods, abnormal heavy bleeding, irregular periods, and menopausal syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Dexamethasone may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using UV spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

其他说明

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7302 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Health hazardEnvironment
GHS08,GHS09

警示用语：

Danger

危险分类

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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UV spectrophotometric method for the estimation of norethindrone in immediate release tablet
Bansal K, et al.
International Journal of Pharmaceutical Sciences and Drug Research, 3(2), 127-129 (2011)
Simultaneous determination of norethindrone and ethinyl estradiol in human plasma by high performance liquid chromatography with tandem mass spectrometry?experiences on developing a highly selective method using derivatization reagent for enhancing sensitivity.
Li W, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 825(2), 223-232 (2005)

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