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PHR1732

盐酸万古霉素

Name: 盐酸万古霉素
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Vancomycin 盐酸盐

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关于此项目

经验公式（希尔记法）:

C₆₆H₇₅Cl₂N₉O₂₄ · xHCl

化学文摘社编号:

1404-93-9

分子量:

1449.25 (free base basis)

UNSPSC Code:

41116107

NACRES:

NA.24

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. V0045000, traceable to USP 1709007

API family

vancomycin

CofA

current certificate can be downloaded

packaging

pkg of 4x250 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

SMILES string

Clc1c2ccc(c1)[C@H]([C@@H]3NC(=O)[C@H](NC(=O)[C@@H]6NC(=O)[C@@H](NC(=O)[C@@H]([C@@H](c7cc(c(cc7)Oc8c(c(cc6c8)O2)O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O[C@@H]%10O[C@H]([C@H]([C@](C%10)(N)C)O)C)O)O)CO)Cl)O)NC(=O)[C@H](NC)CC(C)C)CC(=O)N)c4cc(c(cc4)O)c5c(cc(cc5O)

InChI

1S/C66H75Cl2N9O24.ClH/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92;/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95);1H/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-;/m0./s1

InChI key

LCTORFDMHNKUSG-XTTLPDOESA-N

说明

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Vancomycin hydrochloride is a glycopeptide antibiotic, effective for the treatment of endocarditis caused by Gram-positive bacteria. It is used to inhibit the synthesis of bacterial cell wall and prevents the synthesis of peptidoglycan by binding tightly to peptides containing D-alanyl-D-alanine at the free carboxyl end. It is isolated from both Streotomyces orientalis and Nocardia lurida.

Application

Vancomycin hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, pure form and injections preparations using high-performance liquid chromatography technique and spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

To see an example of a Certificate of Analysis for this material enter LRAC0718 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

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pictograms

GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

pcodes

P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313

法规信息

涉药品监管产品

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Effects of Sterilization Techniques on Bioactivity of Polymethyl Methacrylate Antibiotic Beads Containing Vancomycin and Tobramycin.

James Shaw et al.

Journal of orthopaedic trauma, 34(4), e109-e113 (2020-03-21)

Prefabrication and storage of antibiotic beads may decrease surgical time and allow for use in other settings. This study investigated the effects of sterilization technique and storage time on the bioactivity of antibiotic polymethyl methacrylate (PMMA) beads. Uniform beads of

Development and validation of high-performance liquid chromatographic method for the simultaneous determination of ceftriaxone and vancomycin in pharmaceutical formulations and biological samples

Tariq A, et al.

ScienceAsia, 36(4), 297-304 (2010)

Flow Injection-Spectrophotometric Determination of Vancomycin Hydrochloride in Pharmaceutical Preparations Using Diazotized Metoclopramide

Al-Abachi QM, et al.

Journal of Al-Nahrain University, 18(1), 9-19 (2015)

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全球贸易项目编号

货号	GTIN
PHR1732-4X250MG	04061835238224