PHR1752
安非他酮相关化合物A
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
2-(tert-Butylamino)-4′-chloropropiophenone hydrochloride, 2-(tert-butylamino)-3’-bromopiophenone hydrochloride
等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to USP 1078744
API类
bupropion
CofA
current certificate can be downloaded
包装
pkg of 30 mg
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
Clc1ccc(cc1)C(=O)C(NC(C)(C)C)C.Cl
InChI
1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-5-7-11(14)8-6-10;/h5-9,15H,1-4H3;1H
InChI key
DGJAXLCGRQSHOO-UHFFFAOYSA-N
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相关类别
一般描述
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Bupropion hydrochloride (BUP) and its derivatives belong to a chemical class of aminoketones and are known for their antidepressant abilities. BUP selectively inhibits the neuronal reabsorption of catecholamines (noradrenalin and dopamine), has minimal effect on the recapture of indolamines (serotonin) and no inhibitory effect on monoamine oxidase. It is used as the non-nicotine pharmacological therapy for combating smoking in controlled release form.
Bupropion hydrochloride (BUP) may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric and chromatographic techniques.
Bupropion hydrochloride (BUP) and its derivatives belong to a chemical class of aminoketones and are known for their antidepressant abilities. BUP selectively inhibits the neuronal reabsorption of catecholamines (noradrenalin and dopamine), has minimal effect on the recapture of indolamines (serotonin) and no inhibitory effect on monoamine oxidase. It is used as the non-nicotine pharmacological therapy for combating smoking in controlled release form.
Bupropion hydrochloride (BUP) may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric and chromatographic techniques.
应用
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
分析说明
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
其他说明
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7916 in the slot below. This is an example certificate only and may not be the lot that you receive.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Structures from powders: Bupropion hydrochloride
Maccaroni E, et al
Journal of Pharmaceutical and Biomedical Analysis, 50(2), 257-261 (2009)
Use of charge transfer complexation reaction for the spectrophotometric determination of bupropion in pharmaceuticals and spiked human urine.
Basavaiah K and Abdulrahman SAM
The Thai Journal of Pharmaceutical Sciences, 34(4), 257-261 (2010)
Determination of bupropion using liquid chromatography with fluorescence detection in pharmaceutical preparations, human plasma and human urine
Ulu ST and Tuncel M
Journal of Chromatographic Science, 50(5), 433-439 (2012)
Spectroscopic investigations on the inclusion interaction between hydroxypropyl-β-cyclodextrin and bupropion
Misiuk W and Zalewska M
Journal of Molecular Liquids, 159(3), 220-225 (2011)
The determination of bupropion hydrochloride in pharmaceutical dosage forms by original UV and second derivative UV spectrophotometry, potentiometric and conductometric methods
Yeniceli D and Dogrukal AKD
Turkish Journal of Pharmaceutical Sciences, 7, 99-110 (2010)
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