PHR1763
Cefepime hydrochloride
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
Cefepime hydrochloride, Cefepime dihydrochloride monohydrate
SMILES string
[s]1[c]([nH]c(c1)\C(=N\OC)\C(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)[O-])C[N+]4(CCCC4)C)=N.Cl.Cl.O
InChI
1S/C19H24N6O5S2.2ClH.H2O/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11;;;/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29);2*1H;1H2/b23-12-;;;/t13-,17-;;;/m1.../s1
InChI key
LRAJHPGSGBRUJN-OMIVUECESA-N
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. Y0000633, traceable to USP 1097636
API family
cefepime
CofA
current certificate can be downloaded
packaging
pkg of 1 g
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
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General description
Cefepime hydrochloride is one of the fourth-generation, semisynthetic, broad-spectrum, cephalosporin β-lactam antibiotic drugs administered parenterally in patients with moderate-to-severe infections like pneumonia, uncomplicated urinary tract infections, skin and soft tissue infections, etc. Its mode of action involves the penetration of outer cell wall of gram negative bacteria.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
Cefepime hydrochloride has been used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry and chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB8503 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Analysis of N-methylpyrrolidine in cefepime hydrochloride by ion chromatography using suppressed conductivity detection with solid-phase extraction pre-treatment
Page N, et al.
Analytical Methods for Therapeutic Drug Monitoring and Toxicology, 6(4), 1248-1253 (2014)
Spectrophotometric determination of cefepime hydrochloride, cefoperazone sodium, ceftazidime pentahydrate. cefuroxime sodium and etamsylate using ammonium molybdate
Elazazy M, et al.
Scientia Pharmaceutica, 71(3), 211-228 (2003)
RP-HPLC method for simultaneous estimation of cefepime hydrochloride and tazobactam sodium in bulk and pharmaceuticals
Tamboli SR and Patil DD
Journal of Chemistry, 2013(4), 1248-1253 (2013)
Development and validation of a green analytical method of RP-HPLC for quantification of Cefepime hydrochloride in pharmaceutical dosage form: Simple, sensitive and economic
Rodrigues DF and Salgado HRN
Current Pharmaceutical Analysis, 12(4), 306-314 (2016)
Lokender Kumar et al.
Frontiers in microbiology, 12, 598498-598498 (2021-02-16)
Pseudomonas aeruginosa utilizes the quorum sensing (QS) system to strategically coordinate virulence and biofilm formation. Targeting QS pathways may be a potential anti-infective approach to treat P. aeruginosa infections. In the present study, we define cephalosporins' anti-QS activity using Chromobacterium
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