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Merck
CN

PHR1789

Supelco

阿霉素 盐酸盐

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

DOX, 多柔比星® 盐酸盐, 羟基柔红霉素 盐酸盐

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About This Item

经验公式（希尔记法）:
C27H29NO11 · HCl
CAS Number:
25316-40-9
分子量:
579.98
Beilstein:
4229251
EC 号:
246-818-3
MDL编号:
MFCD00077757
UNSPSC代码:
41116107
PubChem化学物质编号:
329823614
NACRES:
NA.24

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等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

USP 1225703
traceable to Ph. Eur. D2975000

API类

doxorubicin

表单

powder

CofA

current certificate can be downloaded

包装

pkg of 200 mg

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

216 °C (dec.) (lit.)

应用

pharmaceutical (small molecule)

储存温度

-10 to -25°C

SMILES字符串

Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO

InChI

1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

InChI key

MWWSFMDVAYGXBV-RUELKSSGSA-N

基因信息

human ... TOP2A(7153)

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相关类别

一般描述

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Doxorubicin Hydrochloride is an anthracycline antibiotic, known for its broad range anti-cancer activities.

应用

This pharmaceutical secondary standard can also be used as follows:
  • Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method combined with UV detection to determine doxorubicin hydrochloride in plasma samples
  • Electrochemical determination of doxorubicin by spinel-structured cobalt ferrite (CoFe2O4) modified carbon paste electrode in biological fluid and injection samples
  • Determination of doxorubicin hydrochloride in human plasma samples using a graphene quantum dots (GQDs) based electrochemical sensor
  • RP-HPLC method-based quantitative analysis of doxorubicin hydrochloride in vacuum foam dried formulations
  • Voltammetric determination of doxorubicin hydrochloride and dastinib using zinc oxide (ZnO) nanoparticle/1-butyl-3-methylimidazolium tetra-fluoroborate modified carbon paste electrode (ZnO-NPs/BMTFB/CPE) in their combined injection samples

分析说明

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

其他说明

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
To see an example of a Certificate of Analysis for this material enter LRAB3692 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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