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Merck
CN

PHR1813

格列吡嗪相关化合物A

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

N-{2-[4-(Aminosulfonyl)phenyl]ethyl}-5-methyl-2-pyrazinecarboxamide, N-{2-[(4-aminosulfonyl)phenyl]ethyl}-5-methyl-pyrazinecarboxamide, 4-[2-(5-Methylpyrazine-2-carboxamido)ethyl]benzenesulfonamide

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关于此项目

经验公式（希尔记法）:
C14H16N4O3S
化学文摘社编号:
33288-71-0
分子量:
320.37
UNSPSC Code:
41116107
NACRES:
NA.24

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grade

certified reference material, pharmaceutical secondary standard

SMILES string

[S](=O)(=O)(N)c1ccc(cc1)CCNC(=O)c2ncc(nc2)C

InChI

1S/C14H16N4O3S/c1-10-8-18-13(9-17-10)14(19)16-7-6-11-2-4-12(5-3-11)22(15,20)21/h2-5,8-9H,6-7H2,1H3,(H,16,19)(H2,15,20,21)

InChI key

IMEZLHZLIANIAS-UHFFFAOYSA-N

agency

traceable to Ph. Eur. G0342000, traceable to USP 1292609

API family

glipizide

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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相关类别

General description

Glipizide is an oral antidiabetic drug that belongs to the class of second-generation sulfonylureas. It is used in the treatment of type 2 diabetes mellitus. It exerts its action by lowering the blood glucose levels via stimulation of insulin release from the β-cells of the pancreas. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Glipizide Related Compound A may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA8813 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Glipizide
USP42/NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 32(5)(4), 2066-2066 (2018)
Development and validation of an UPLC method for in-vitro study of glipizide extended release tablets
Trivedi HK
International Journal of Pharma Sciences and Research, 3(9), 3317- 3322 (2012)
Sulfonylureas and their use in clinical practice
Sola D, et al.
Archives of Medical Science : Ams, 11(4), 840-840 (2015)

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