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Merck
CN

PHR1842

Supelco

Fluticasone Related Compound A

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

6ALPHA,9-DIFLUORO-11BETA-HYDROXY- 16ALPHA-METHYL-3-OXO-17 (PROPANOYLOXY)ANDROSTA-1,4-DIEN- 17BETA-CARBO(THIOPEROXOIC)SO-ACID (Fluticasone Related Compound A) (Fluticasone Impurity B), 6ALPHA,9-DIFLUORO-11BETA-HYDROXY- 16ALPHA-METHYL-3-OXO-17 (PROPANOYLOXY)ANDROSTA-1,4-DIEN- 17BETA-CARBO(THIOPEROXOIC)SO-ACID, ((6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbo(thioperoxoic)o-acid)

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关于此项目

经验公式（希尔记法）:
C24H30F2O6S
化学文摘社编号:
948566-12-9
分子量:
484.55
UNSPSC代码:
41116107
NACRES:
NA.24

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等级

certified reference material
pharmaceutical secondary standard

质量水平

300

API类

fluticasone

CofA

current certificate can be downloaded

包装

pkg of 50 mg

应用

pharmaceutical small molecule

包装形式

neat

储存温度

2-8°C

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相关类别

一般描述

Fluticasone Related Compound B is an impurity of the synthetic corticosteroid drug, fluticasone propionate. Fluticasone propionate is generally used as an inhalation medication for the treatment of asthma.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

Fluticasone Related Compound B may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB2754 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H317,H334

危险分类

Resp. Sens. 1 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Comparative evaluation of the leukotriene receptor antagonist pranlukast versus the steroid inhalant fluticasone in the therapy of aged patients with mild bronchial asthma
Horiguchi T, et al.
Arzneimittelforschung, 57(02), 87-91 (2007)
Fluticasone propionate
USP42/NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 32(2), 1940-1940 (2014)
Method Development and Validation of Simultaneous Determination of Related Substances for Salmeterol Xinafoate and Fluticasone Propionate in Dry Powder Inhalers
Arzu C, et al.
Chromatography, 10(02), 87-91 (2017)

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