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Merck
CN

PHR1998

硫胺杂质C

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Beclotiamine

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关于此项目

NACRES:
NA.24
UNSPSC Code:
41116107
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grade

certified reference material, pharmaceutical secondary standard

API family

thiamine

CofA

current certificate can be downloaded

packaging

pkg of 20 mg

application(s)

pharmaceutical small molecule

format

neat

storage temp.

2-8°C

Quality Level

General description

Thiamine Impurity C is a pharmaceutical impurity of thiamine belonging to B group vitamins important for primary metabolism in all living organisms. Thiamine is widely used in the treatment or prevention of beriberi.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Thiamine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using flow injection turbidimetric method and UV-Vis spectrophotometry.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB8021 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark

signalword

Warning

hcodes

pcodes

Hazard Classifications

Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


分析证书(COA)

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Flow injection turbidimetric determination of thiamine in pharmaceutical formulations using silicotungstic acid as precipitant reagent
Costa-Neto OC, et al.
Talanta, 48(3), 659-667 (1999)
B Group Vitamins: Current Uses and Perspectives, 48(3), 659-667 (2018)
Simultaneous determination and classification of riboflavin, thiamine, nicotinamide and pyridoxine in pharmaceutical formulations, by UV-visible spectrophotometry and multivariate analysis
Lopez-de-Alba LP, et al.
Journal of the Brazilian Chemical Society, 17(4), 715-722 (2006)

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