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About This Item
经验公式（希尔记法）:
C3H4N2
CAS Number:
分子量:
68.08
Beilstein:
103853
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.21
等级
Molecular Biology
质量水平
蒸汽压
<1 mmHg ( 20 °C)
产品线
Redi-Dri™
方案
≥99% (titration)
表单
crystalline powder
质量
free-flowing
pH值（酸碱度）
6.2-7.8 (25 °C)
pKa (25 °C)
6.95
沸点
256 °C (lit.)
mp
88-91 °C (lit.)
应用
diagnostic assay manufacturing
异质活性
DNase, RNase and protease, none detected
SMILES字符串
c1c[nH]cn1
InChI
1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
InChI key
RAXXELZNTBOGNW-UHFFFAOYSA-N
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一般描述
Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar.
应用
特别适用于 pH 6.2-7.8 范围内的缓冲液
Imidazole has been used
- in the lysis, wash, and elution buffer for the purification of histidine tagged proteins
- in gradient for the purification of histidine tagged proteins using nickel affinity chromatography
- as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells
生化/生理作用
Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).
特点和优势
- Qualified for molecular biology applications, DNase, Rnase, and protease free
- Redi-Dri™ packaging controls moisture, eliminating clumps
- Crystalline powder remains free-flowing and much easier to use
- Safer to handle and weigh out for routine use in lab
- Less waste, loss of drying, while maintaining high quality
其他说明
For additional information on our range of Biochemicals, please complete this form.
法律信息
Redi-Dri is a trademark of Sigma-Aldrich Co. LLC
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1C
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
闪点(°F)
293.0 °F - closed cup
闪点(°C)
145 °C - closed cup
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