RDD043
氯化乙酰胆碱
≥99% (TLC), free-flowing, Redi-Dri™
别名:
ACh
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关于此项目
线性分子式:
(CH3)3N+CH2CH2OCOCH3Cl-
化学文摘社编号:
分子量:
181.66
NACRES:
NA.25
UNSPSC Code:
51151535
Beilstein/REAXYS Number:
3571875
MDL number:
产品名称
氯化乙酰胆碱, ≥99% (TLC), free-flowing, Redi-Dri™
SMILES string
[Cl-].CC(=O)OCC[N+](C)(C)C
InChI
1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
InChI key
JUGOREOARAHOCO-UHFFFAOYSA-M
product line
Redi-Dri™
assay
≥99% (TLC)
form
powder
quality
free-flowing
packaging
pkg of 100 g
color
white to faint yellow cast
mp
146-150 °C (lit.)
solubility
H2O: 100 mg/mL
density
1.27 g/cm3
storage temp.
room temp
Quality Level
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Biochem/physiol Actions
氯化乙酰胆碱，20mg/kg体重注射，减少小鼠实验性诱发脓毒病的死亡和血浆促炎细胞因子。类胆碱能抗-炎症机制可能通过乙酰胆碱和 α7n单核细胞，巨噬细胞和中性粒细胞上的胆红素受体互作接待，降低了促炎细胞活素，比如 TNF-α,IL-1β,和IL-6。
胆碱能突触中的内源性神经递质，通过增强肌膜动作电位来触发肌肉收缩反应。
Disclaimer
非常吸湿
Application
Acetylcholine chloride has been used:
- as an agent to trigger sudomotor axon reflex response during autonomic test
- to induce contraction amplitude of pyloric circular smooth muscle strip (PCSMS) in rats
- as a substrate for acetylcholinesterase
- to stimulate after discharge in Aplysia bag cell neurons
Features and Benefits
- Redi-Dri™ format for Improved Efficiency and Time Savings
- Can be used in Metabolomics and Biochemical research
- High-quality compound suitable for multiple research applications
General description
Acetylcholine Chloride, the chloride salt of acetylcholine, is a synthetic amino alcohol with cholinergic properties, making it a vital component in biochemical and neurotransmission studies. It replicates the effects of the endogenous acetylcholine compound, which plays a significant role in the immune system, inflammation, and allergy research. Acetylcholine chloride acts as a cholinergic neurotransmitter, binding to nicotinic and muscarinic acetylcholine receptors, facilitating the opening of calcium channels.Furthermore, Acetylcholine chloride (ACh chloride) functions as a potent cholinergic agonist, influencing the activity of dopaminergic (DAergic) neurons by stimulating nicotinic acetylcholine receptors (nAChRs). This feature is particularly relevant in studies related to the immune system and inflammation. Additionally, it demonstrates the capacity to inhibit the aggregation of p53 mutant peptide in vitro, which contributes to the exploration of biochemical and allergy research.
Other Notes
For additional information on our range of Biochemicals, please complete this form.
Legal Information
Redi-Dri is a trademark of Sigma-Aldrich Co. LLC
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Stability of acetylcholine chloride solution in autonomic testing
Sletten DM, et al.
Journal of the Neurological Sciences, 234(1-2), 1-3 (2005)
Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation.
Young A and Levin RJ
Gut, 31(2), 162-169 (1990)
Acetylcholine Chloride: Physical Profile
Profiles of Drug Substances, Excipients, and Related Methodology, 31, 1-19 (2005)
Acetylcholine-evoked afterdischarge in Aplysia bag cell neurons
White SH and Magoski NS
American Journal of Physiology. Heart and Circulatory Physiology (2012)
Qing Cao et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 23(14), 1797-1805 (2016-12-04)
Radix Polygalae, the dried root of Polygala tenuifolia, has been extensively used as a traditional Chinese medicine for promoting intelligence and tranquilization. Polygalasaponins extracted from the root of P. tenuifolia possess evident anxiolytic and sedative-hypnotic activities. Previous studies have reported
商品
Redi-Dri™ prevents hygroscopic powders, such as inorganic salts, from absorbing moisture and forming clumps, leaving the salts free-flowing every time.
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