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Merck
CN

S0883

柳氮磺胺吡啶

97.0-101.5%

别名:

2-羟基-5-\ { \ { 4-[（2-吡啶氨基）磺酰基]苯基}偶氮}苯甲酸, 5-[对-(2-吡啶胺磺酰基)苯]偶氮水杨酸, 柳氮磺胺吡啶

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关于此项目

经验公式（希尔记法）:
C18H14N4O5S
化学文摘社编号:
599-79-1
分子量:
398.39
Beilstein:
356241
EC 号:
209-974-3
MDL编号:
MFCD00057363
UNSPSC代码:
41116107
PubChem化学物质编号:
329824182
NACRES:
NA.24

主要文件

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质量水平

200

方案

97.0-101.5%

表单

powder

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

260-265 °C (dec.) (lit.)

应用

forensics and toxicology
pharmaceutical (small molecule)

作用机制

DNA synthesis | interferes
enzyme | inhibits

SMILES字符串

OC(=O)c1cc(ccc1O)\N=N\c2ccc(cc2)S(=O)(=O)Nc3ccccn3

InChI

1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+

InChI key

NCEXYHBECQHGNR-QZQOTICOSA-N

基因信息

human ... ALOX5(240), PTGS1(5742), PTGS2(5743)

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相关类别

一般描述

化学结构：磺胺
柳氮磺胺吡啶(SSZ)属于磺胺类药物，可代谢为5-氨基水杨酸和磺胺吡啶。SSZ是抗菌剂（磺胺吡啶）和消炎剂（水杨酸）的反应产物。

应用

有关合适仪器技术的更多信息，请参考产品的分析证书。如需进一步支持，请联系技术服务。
柳氮磺胺吡啶在临床研究中用作分析标准品：
  • 研究其对多发性硬化症(MS)患者的治疗潜力。
  • 通过抑制试验动物大鼠骨关节炎进展相关的软骨退变和疼痛研究其作为抗关节炎药物的作用。

此外，还可作为分析参考标准，以通过酶联免疫吸附试验(ELISA)和荧光分光度技术量化生物样本和水样中的分析物。



象形图

Health hazardEnvironment
GHS08,GHS09

警示用语：

Danger

危险分类

Aquatic Chronic 2 - Carc. 2 - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 2

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000478691
0000478691
0000458207
0000458207
0000426454

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Johan A Karlsson et al.
Annals of the rheumatic diseases, 72(12), 1927-1933 (2012-12-01)
To compare EuroQol 5-Dimensions (EQ-5D) utility and quality-adjusted life-years (QALYs) in patients with early, methotrexate (MTX) refractory rheumatoid arthritis (RA), randomised to addition of infliximab (IFX) or sulfasalazine and hydroxychloroquine (SSZ+HCQ). RA-patients with symptoms <1 year were enrolled between 2002
Maarten Boers et al.
Annals of the rheumatic diseases, 72(3), 406-409 (2012-11-17)
Treatment of rheumatoid arthritis (RA) with tumour necrosis factor (TNF) antagonists changes the relationship between disease activity and progression of radiological joint damage ('disconnect'): patients who have little or no response of disease activity still show reductions in damage progression.
M van den Broek et al.
Clinical and experimental rheumatology, 30(4 Suppl 73), S35-S38 (2012-10-20)
Targeted treatment is effective in the short term in achieving low disease activity or even remission in patients with rheumatoid arthritis (RA). The benefits of long-term targeted treatment are discussed based on the BeSt study results. The BeSt study has
Sushil Kumar et al.
The Cochrane database of systematic reviews, 10, CD008424-CD008424 (2012-10-19)
Ulcerative colitis (UC) is a chronic inflammatory condition of the colon characterized by episodes of disease activity and symptom-free remission.There is paucity of evidence regarding the efficacy and safety of complementary or alternative medicines for the management of UC. Curcumin
Shekoufeh Nikfar et al.
Digestive diseases and sciences, 54(6), 1157-1170 (2008-09-05)
Historically, sulfasalazine (SSZ) and 5-aminosalicylates (5-ASAs) have been a mainstay of mild-to-moderate ulcerative colitis (UC) remission induction and maintenance therapy. Considering the pivotal role of intestinal microbial flora in pathophysiology of UC and antimicrobial activity of sulfapyridine, we hypothesized that
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