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Merck
CN

S0929

Sigma-Aldrich

东莨菪碱 氢溴酸盐

meets USP testing specifications

别名:

(-)-东莨菪碱 氢溴酸盐 三水合物, 天仙子碱 氢溴酸盐, 莨菪胺

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关于此项目

经验公式（希尔记法）:
C17H21NO4 · HBr · 3H2O
化学文摘社编号:
6533-68-2
分子量:
438.31
Beilstein:
6100669
MDL编号:
MFCD00150066
UNSPSC代码:
12352116
PubChem化学物质编号:
24899453
NACRES:
NA.21

主要文件

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Agency

USP/NF
meets USP testing specifications

质量水平

200

mp

195-199 °C (dry matter) (lit.)

应用

pharmaceutical (small molecule)

SMILES字符串

O.O.O.Br.CN1[C@@H]2C[C@H](C[C@H]1[C@@H]3O[C@H]23)OC(=O)[C@H](CO)c4ccccc4

InChI

1S/C17H21NO4.BrH.3H2O/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;;;;/h2-6,11-16,19H,7-9H2,1H3;1H;3*1H2/t11-,12-,13-,14+,15-,16+;;;;/m1..../s1

InChI key

LACQPOBCQQPVIT-SEYKEWMNSA-N

基因信息

human ... CHRM1(1128)

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应用

Scopolamine hydrobromide has been used as a muscarinic receptor antagonist:
  • to reverse the cardiac effects of physostigmine in rabbit heart
  • to study its effect on acoustic startle reflex (gap-PPI){148)
  • to study it′s in vitro antiviral, antibacterial, and antifungal activities and cytotoxicity
  • to study its effect on conditioning of lever pressing

生化/生理作用

竞争性非选择性毒蕈碱型乙酰胆碱拮抗剂。
竞争性非选择性毒蕈碱型乙酰胆碱拮抗剂。东莨菪碱所致的实验室动物记忆障碍是常用的记忆缺陷模型。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300 + H310 + H330

危险分类

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000281189
0000281202
SLCP6341
0000281201
0000281189

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Effects of Scopolamine on Conditioning of Lever Pressing
Juarez Y, et al.
Acta Acad. Med. Sin., 1(1), 14-23 (2011)
Bardia Nouriziabari et al.
Journal of Alzheimer's disease : JAD, 63(2), 725-740 (2018-04-18)
Trace eyeblink conditioning is a hippocampus-dependent associative learning paradigm which is impaired in patients with Alzheimer's disease (AD) and animal AD models. Learning in this paradigm accompanies changes in oscillatory activity in forebrain regions, some of which are loci of
Patrizia Giannoni et al.
The Journal of pharmacology and experimental therapeutics, 332(1), 164-172 (2009-10-10)
After oral administration, the nonimidazole histamine H(3) receptor antagonist, 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254), increased histamine release from the tuberomammillary nucleus, where all histaminergic somata are localized, and from where their axons project to the entire brain. To further understand functional histaminergic
Gareth R I Barker et al.
Learning & memory (Cold Spring Harbor, N.Y.), 16(1), 8-11 (2009-01-02)
Object-in-place memory, which relies on the formation of associations between an object and the place in which it was encountered, depends upon a neural circuit comprising the perirhinal (PRH) and medial prefrontal (mPFC) cortices. This study examined the contribution of
Reversal of cardiac vagal effects of physostigmine by adjunctive muscarinic blockade
Winter J, et al.
Neurotoxicology, 57, 174-182 (2016)
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