Novobiocin Ready Made Solution

Name: Novobiocin Ready Made Solution
Brand: SIAL

100 mg/mL in water

别名:

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About This Item

线性分子式:

C₃₁H₃₅N₂NaO₁₁

分子量:

634.61

UNSPSC代码:

51286504

NACRES:

NA.76

生物来源

microbial

质量水平

100

方案

≥90%

表单

liquid
ready-to-use solution

浓度

100 mg/mL in water

颜色

faint yellow to dark brown

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
neoplastics

作用机制

DNA synthesis | interferes
enzyme | inhibits

储存温度

−20°C

一般描述

Novobiocin, also known as albamycin or cathomycin, is an aminocoumarin antibiotic commonly derived from Streptomyces Sp. It exerts its antibacterial activity by inhibiting Topo II α, which corresponds to bacterial DNA gyrase. It is effective against both gram-positive and gram-negative bacteria and is significant in research involving highly beta-lactam-resistant pneumococcal infections and anti-orthopoxvirus applications. Functioning as a competitive inhibitor in the ATPase reaction catalyzed by GyrB, Novobiocin is employed in microbiology and cell biology research to effectively prevent the growth of bacterial contaminants.

应用

Novobiocin has been used:

in cell culture systems to treat mycoplasma contaminations.[3]
in a research to where it has exhibited anti-cancer effects by inhibition of Hsp90 (heat shock protein)[4],[5]

生化/生理作用

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II

Activity spectrum: Active against gram-positive and gram-negative bacteria

特点和优势

Ready available solution reduce the need for preparation time
Commonly used in Cell Biology and Biochemical applications
High quality antibiotic suitable for mulitple research applications

制备说明

Novobiocin Ready Made Solution is light sensitive. Thaw this product at room temperature. It is recommended to avoid repeated freeze thaw cycles of this product. The suggested concentration of Novobiocin for cell culture assays is 50-1000 μg/mL,^,, therefore, it is recommended to dilute the Ready Made Solution 1:100-2000.