SMB00969
阿米替林代谢物，(±)-E-10-羟基化-
≥95% (HPLC)
别名:
(±)-E-5-[3-(二甲氨基)丙叉基]-10.11-二氢-5H-二苯并[a,d]环庚烯-10-醇
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关于此项目
经验公式（希尔记法）:
C20H23NO
化学文摘社编号:
分子量:
293.40
UNSPSC Code:
41116107
NACRES:
NA.77
MDL number:
产品名称
阿米替林代谢物，(±)-E-10-羟基化-, ≥95% (HPLC)
InChI
1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+
SMILES string
CN(C)CC\C=C1/c2ccccc2CC(O)c3ccccc13
InChI key
GHWBJXOKAFHZAI-SFQUDFHCSA-N
assay
≥95% (HPLC)
form
solid
technique(s)
HPLC: suitable
color
white to yellow
storage temp.
2-8°C
Quality Level
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Biochem/physiol Actions
阿米替林代谢物，三环抗抑郁剂；色谱标准品。
Application
Metabolomics research
General description
(E)-10-Hydroxy amitriptyline is a metabolite of Amitriptyline (brand name Elavil), a FDA-approved oral medicine for the treatment of major depressive and anxiety disorders, attention deficit hyperactivity disorder (ADHD), bipolar disorder, as well as migraines and neuropathic pain (fibromyalgia & postherpetic neuralgiapain). Amitriptyline acts mainly on the serotonin transporter (SERT) and moderately on the norepinephrine transporter (NET). Amitriptyline is metabolised by cytochrome P450 enzymes (demethylation by CYP2C19 & CYP3A4) in the liver to Nortriptyline, which also acts as a noradrenaline reuptake inhibitor and thereby potentiates the antidepressant effects of amitriptyline. Amitriptyline and Nortriptyline are subject to metabolisation by hydroxylation (by CYP2D6) and n-oxidation.
Other Notes
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Ursula Breyer-Pfaff
Drug metabolism reviews, 36(3-4), 723-746 (2004-11-24)
Amitriptyline (AT), the most widely used tricyclic antidepressant, undergoes oxidative metabolism in the side chain with production of the secondary amine nortriptyline (NT), a primary amine, and the N-oxide amitriptylinoxide (AT-NO); in addition, direct conjugation leads to a quaternary ammonium-linked
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